TSC complex subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
kidney development [GO:0001822],
neural tube closure [GO:0001843],
regulation of cell-matrix adhesion [GO:0001952],
adaptive immune response [GO:0002250],
rRNA export from nucleus [GO:0006407],
regulation of translation [GO:0006417],
potassium ion transport [GO:0006813],
cell-matrix adhesion [GO:0007160],
negative regulation of cell proliferation [GO:0008285],
adult locomotory behavior [GO:0008344],
negative regulation of neuron projection development [GO:0010977],
positive regulation of macroautophagy [GO:0016239],
negative regulation of macroautophagy [GO:0016242],
negative regulation of translation [GO:0017148],
hippocampus development [GO:0021766],
cerebral cortex development [GO:0021987],
cell projection organization [GO:0030030],
negative regulation of TOR signaling [GO:0032007],
negative regulation of ATPase activity [GO:0032780],
response to insulin [GO:0032868],
negative regulation of GTPase activity [GO:0034260],
myelination [GO:0042552],
memory T cell differentiation [GO:0043379],
regulation of phosphoprotein phosphatase activity [GO:0043666],
negative regulation of cell size [GO:0045792],
regulation of protein kinase activity [GO:0045859],
glucose import [GO:0046323],
negative regulation of insulin receptor signaling pathway [GO:0046627],
synapse organization [GO:0050808],
protein stabilization [GO:0050821],
regulation of stress fiber assembly [GO:0051492],
positive regulation of stress fiber assembly [GO:0051496],
regulation of cell cycle [GO:0051726],
positive regulation of focal adhesion assembly [GO:0051894],
cardiac muscle cell differentiation [GO:0055007],
activation of GTPase activity [GO:0090630],
cellular response to oxygen-glucose deprivation [GO:0090650],
regulation of neuron death [GO:1901214],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
nervous system development [GO:0007399],
embryo development [GO:0009790],
regulation of focal adhesion assembly [GO:0051893],

Molecular Function:
protein binding [GO:0005515],
Hsp70 protein binding [GO:0030544],
GTPase activating protein binding [GO:0032794],
ATPase inhibitor activity [GO:0042030],
macromolecular complex binding [GO:0044877],
protein N-terminus binding [GO:0047485],
chaperone binding [GO:0051087],
Hsp90 protein binding [GO:0051879],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lipid particle [GO:0005811],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
lamellipodium [GO:0030027],
growth cone [GO:0030426],
macromolecular complex [GO:0032991],
TSC1-TSC2 complex [GO:0033596],
perinuclear region of cytoplasm [GO:0048471],
cytoskeleton [GO:0005856],
cell projection [GO:0042995],
intracellular membrane-bounded organelle [GO:0043231],