TRPV4

transient receptor potential cation channel subfamily V member 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
diet induced thermogenesis [GO:0002024],
calcium ion transport [GO:0006816],
cellular calcium ion homeostasis [GO:0006874],
cell volume homeostasis [GO:0006884],
actin filament organization [GO:0007015],
cell-cell junction assembly [GO:0007043],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
osmosensory signaling pathway [GO:0007231],
response to mechanical stimulus [GO:0009612],
positive regulation of macrophage chemotaxis [GO:0010759],
negative regulation of neuron projection development [GO:0010977],
vasopressin secretion [GO:0030103],
positive regulation of microtubule depolymerization [GO:0031117],
actin cytoskeleton reorganization [GO:0031532],
response to insulin [GO:0032868],
cellular response to heat [GO:0034605],
hyperosmotic salinity response [GO:0042538],
glucose homeostasis [GO:0042593],
positive regulation of vascular permeability [GO:0043117],
cortical microtubule organization [GO:0043622],
positive regulation of JNK cascade [GO:0046330],
microtubule polymerization [GO:0046785],
regulation of response to osmotic stress [GO:0047484],
positive regulation of inflammatory response [GO:0050729],
multicellular organismal water homeostasis [GO:0050891],
cartilage development involved in endochondral bone morphogenesis [GO:0060351],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
calcium ion import [GO:0070509],
calcium ion transmembrane transport [GO:0070588],
cellular response to osmotic stress [GO:0071470],
cellular hypotonic response [GO:0071476],
cellular hypotonic salinity response [GO:0071477],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642],
positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651],
energy homeostasis [GO:0097009],
blood vessel endothelial cell delamination [GO:0097497],
calcium ion import across plasma membrane [GO:0098703],
calcium ion import into cytosol [GO:1902656],
negative regulation of brown fat cell differentiation [GO:1903444],
positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340],
positive regulation of interleukin-6 secretion [GO:2000778],
ion transport [GO:0006811],
response to osmotic stress [GO:0006970],
hypotonic response [GO:0006971],
positive regulation of gene expression [GO:0010628],
response to lipopolysaccharide [GO:0032496],
transmembrane transport [GO:0055085],
response to fatty acid [GO:0070542],
regulation of p38MAPK cascade [GO:1900744],

Molecular Function:
actin binding [GO:0003779],
osmosensor activity [GO:0005034],
protein kinase C binding [GO:0005080],
ion channel activity [GO:0005216],
cation channel activity [GO:0005261],
calcium channel activity [GO:0005262],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
microtubule binding [GO:0008017],
lipid binding [GO:0008289],
stretch-activated, cation-selective, calcium channel activity [GO:0015275],
protein kinase binding [GO:0019901],
SH2 domain binding [GO:0042169],
identical protein binding [GO:0042802],
alpha-tubulin binding [GO:0043014],
metal ion binding [GO:0046872],
beta-tubulin binding [GO:0048487],
actin filament binding [GO:0051015],
nucleotide binding [GO:0000166],

Cellular Component:
endoplasmic reticulum [GO:0005783],
cytoplasmic microtubule [GO:0005881],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
cilium [GO:0005929],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
apical plasma membrane [GO:0016324],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
growth cone [GO:0030426],
cortical actin cytoskeleton [GO:0030864],
cytoplasmic vesicle [GO:0031410],
ruffle membrane [GO:0032587],
membrane [GO:0016020],
cell junction [GO:0030054],
cell projection [GO:0042995],