transient receptor potential cation channel subfamily V member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
fever generation [GO:0001660],
microglial cell activation [GO:0001774],
diet induced thermogenesis [GO:0002024],
peptide secretion [GO:0002790],
negative regulation of systemic arterial blood pressure [GO:0003085],
lipid metabolic process [GO:0006629],
cell surface receptor signaling pathway [GO:0007166],
chemosensory behavior [GO:0007635],
negative regulation of heart rate [GO:0010459],
negative regulation of mitochondrial membrane potential [GO:0010917],
glutamate secretion [GO:0014047],
cellular response to heat [GO:0034605],
positive regulation of apoptotic process [GO:0043065],
response to peptide hormone [GO:0043434],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
behavioral response to pain [GO:0048266],
sensory perception of mechanical stimulus [GO:0050954],
thermoception [GO:0050955],
detection of temperature stimulus involved in thermoception [GO:0050960],
detection of temperature stimulus involved in sensory perception of pain [GO:0050965],
detection of chemical stimulus involved in sensory perception of pain [GO:0050968],
release of sequestered calcium ion into cytosol [GO:0051209],
protein homotetramerization [GO:0051289],
excitatory postsynaptic potential [GO:0060079],
smooth muscle contraction involved in micturition [GO:0060083],
positive regulation of gastric acid secretion [GO:0060454],
calcium ion transmembrane transport [GO:0070588],
cellular response to alkaloid [GO:0071312],
cellular response to ATP [GO:0071318],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to acidic pH [GO:0071468],
cellular response to temperature stimulus [GO:0071502],
negative regulation of establishment of blood-brain barrier [GO:0090212],
calcium ion import across plasma membrane [GO:0098703],
response to capsazepine [GO:1901594],
cellular response to nerve growth factor stimulus [GO:1990090],
temperature homeostasis [GO:0001659],
ion transport [GO:0006811],
cation transport [GO:0006812],
calcium ion transport [GO:0006816],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
response to pH [GO:0009268],
response to heat [GO:0009408],
response to organonitrogen compound [GO:0010243],
urinary bladder smooth muscle contraction [GO:0014832],
sensory perception of pain [GO:0019233],
ion transmembrane transport [GO:0034220],
catagen [GO:0042637],
response to pain [GO:0048265],
transmembrane transport [GO:0055085],
cellular response to cytokine stimulus [GO:0071345],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
ion channel activity [GO:0005216],
extracellular ligand-gated ion channel activity [GO:0005230],
excitatory extracellular ligand-gated ion channel activity [GO:0005231],
calcium channel activity [GO:0005262],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
calcium-release channel activity [GO:0015278],
chloride channel regulator activity [GO:0017081],
phosphatidylinositol binding [GO:0035091],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
phosphoprotein binding [GO:0051219],
temperature-gated ion channel activity [GO:0097603],
nucleotide binding [GO:0000166],
cation channel activity [GO:0005261],
cation transmembrane transporter activity [GO:0008324],
ligand-gated ion channel activity [GO:0015276],

Cellular Component:
mitochondrion [GO:0005739],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],
intrinsic component of plasma membrane [GO:0031226],
dendritic spine membrane [GO:0032591],
neuronal cell body [GO:0043025],
postsynaptic membrane [GO:0045211],
membrane [GO:0016020],
cell junction [GO:0030054],
dendrite [GO:0030425],
cell projection [GO:0042995],
neuron projection [GO:0043005],
synapse [GO:0045202],