tripartite motif containing 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
positive regulation of defense response to virus by host [GO:0002230],
positive regulation of cytokine production involved in immune response [GO:0002720],
regulation of gene expression [GO:0010468],
positive regulation of autophagy [GO:0010508],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
free ubiquitin chain polymerization [GO:0010994],
protein ubiquitination [GO:0016567],
regulation of protein stability [GO:0031647],
response to lipopolysaccharide [GO:0032496],
regulation of protein localization [GO:0032880],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
cellular response to interferon-beta [GO:0035458],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
negative regulation of viral genome replication [GO:0045071],
innate immune response [GO:0045087],
negative regulation of transcription, DNA-templated [GO:0045892],
regulation of viral entry into host cell [GO:0046596],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of type I interferon-mediated signaling pathway [GO:0060340],
cellular response to virus [GO:0098586],
positive regulation of transcription regulatory region DNA binding [GO:2000679],
negative regulation of stem cell differentiation [GO:2000737],
viral process [GO:0016032],
regulation of NIK/NF-kappaB signaling [GO:1901222],

Molecular Function:
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
protein binding, bridging [GO:0030674],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
ubiquitin protein ligase activity [GO:0061630],
protein tyrosine kinase binding [GO:1990782],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],