tripartite motif containing 27

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22556269 MEF Mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
protein polyubiquitination [GO:0000209],
negative regulation of adaptive immune response [GO:0002820],
negative regulation of protein kinase activity [GO:0006469],
spermatogenesis [GO:0007283],
regulation of gene expression [GO:0010468],
positive regulation of autophagy [GO:0010508],
protein ubiquitination [GO:0016567],
negative regulation of tumor necrosis factor production [GO:0032720],
regulation of protein localization [GO:0032880],
negative regulation of viral transcription [GO:0032897],
Arp2/3 complex-mediated actin nucleation [GO:0034314],
retrograde transport, endosome to Golgi [GO:0042147],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
innate immune response [GO:0045087],
negative regulation of gene expression, epigenetic [GO:0045814],
regulation of viral entry into host cell [GO:0046596],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of actin nucleation [GO:0051127],
protein K63-linked ubiquitination [GO:0070534],
interferon-gamma secretion [GO:0072643],
negative regulation of calcium ion import [GO:0090281],
negative regulation of interleukin-2 secretion [GO:1900041],
negative regulation of viral release from host cell [GO:1902187],

Molecular Function:
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
protein kinase binding [GO:0019901],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
ubiquitin protein ligase activity [GO:0061630],
transferase activity [GO:0016740],

Cellular Component:
fibrillar center [GO:0001650],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
endosome [GO:0005768],
early endosome [GO:0005769],
cytosol [GO:0005829],
PML body [GO:0016605],
retromer complex [GO:0030904],
nuclear membrane [GO:0031965],