TRIM24

tripartite motif containing 24

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
transcription from RNA polymerase II promoter [GO:0006366],
negative regulation of cell proliferation [GO:0008285],
protein ubiquitination [GO:0016567],
protein catabolic process [GO:0030163],
regulation of protein stability [GO:0031647],
regulation of apoptotic process [GO:0042981],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
protein autophosphorylation [GO:0046777],
calcium ion homeostasis [GO:0055074],
regulation of vitamin D receptor signaling pathway [GO:0070562],
cellular response to estrogen stimulus [GO:0071391],
regulation of signal transduction by p53 class mediator [GO:1901796],
protein phosphorylation [GO:0006468],
positive regulation of gene expression [GO:0010628],

Molecular Function:
p53 binding [GO:0002039],
chromatin binding [GO:0003682],
transcription coactivator activity [GO:0003713],
protein kinase activity [GO:0004672],
receptor binding [GO:0005102],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
ligand-dependent nuclear receptor binding [GO:0016922],
estrogen response element binding [GO:0034056],
methylated histone binding [GO:0035064],
ubiquitin protein ligase activity [GO:0061630],
lysine-acetylated histone binding [GO:0070577],
DNA binding [GO:0003677],
ubiquitin-protein transferase activity [GO:0004842],
transferase activity [GO:0016740],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nuclear euchromatin [GO:0005719],
perichromatin fibrils [GO:0005726],
cytosol [GO:0005829],
intracellular [GO:0005622],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],