TRIM21

tripartite motif containing 21

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32023548 U2OS Human NO
32064156 U-87 Human NO

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
protein monoubiquitination [GO:0006513],
cell cycle [GO:0007049],
regulation of gene expression [GO:0010468],
positive regulation of autophagy [GO:0010508],
protein ubiquitination [GO:0016567],
protein destabilization [GO:0031648],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
regulation of type I interferon production [GO:0032479],
regulation of protein localization [GO:0032880],
negative regulation of viral transcription [GO:0032897],
response to interferon-gamma [GO:0034341],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
innate immune response [GO:0045087],
positive regulation of cell cycle [GO:0045787],
regulation of viral entry into host cell [GO:0046596],
positive regulation of viral entry into host cell [GO:0046598],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
protein autoubiquitination [GO:0051865],
interferon-gamma-mediated signaling pathway [GO:0060333],
negative regulation of protein deubiquitination [GO:0090086],
negative regulation of viral release from host cell [GO:1902187],

Molecular Function:
DNA binding [GO:0003677],
RNA binding [GO:0003723],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
protein kinase binding [GO:0019901],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ubiquitin protein ligase activity [GO:0061630],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
autophagosome [GO:0005776],
cytosol [GO:0005829],
SCF ubiquitin ligase complex [GO:0019005],
cytoplasmic vesicle [GO:0031410],
ribonucleoprotein complex [GO:1990904],