TRIB3

tribbles pseudokinase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30977188 MSC Human YES
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28486108 NB4 Bone marrow Human, mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
protein phosphorylation [GO:0006468],
negative regulation of protein kinase activity [GO:0006469],
regulation of autophagy [GO:0010506],
regulation of glucose transport [GO:0010827],
regulation of lipid metabolic process [GO:0019216],
positive regulation of protein binding [GO:0032092],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
cellular response to insulin stimulus [GO:0032869],
response to endoplasmic reticulum stress [GO:0034976],
regulation of MAP kinase activity [GO:0043405],
negative regulation of fat cell differentiation [GO:0045599],
negative regulation of fatty acid biosynthetic process [GO:0045717],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of ubiquitin-protein transferase activity [GO:0051443],
negative regulation of protein kinase B signaling [GO:0051898],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
apoptotic process [GO:0006915],
positive regulation of protein catabolic process [GO:0045732],

Molecular Function:
transcription corepressor activity [GO:0003714],
protein kinase inhibitor activity [GO:0004860],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
protein kinase binding [GO:0019901],
mitogen-activated protein kinase kinase binding [GO:0031434],
ubiquitin protein ligase binding [GO:0031625],
ubiquitin-protein transferase regulator activity [GO:0055106],
protein kinase activity [GO:0004672],
enzyme binding [GO:0019899],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],