TREM2

triggering receptor expressed on myeloid cells 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
microglial cell activation [GO:0001774],
positive regulation of protein phosphorylation [GO:0001934],
microglial cell activation involved in immune response [GO:0002282],
positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588],
response to ischemia [GO:0002931],
phagocytosis, engulfment [GO:0006911],
humoral immune response [GO:0006959],
regulation of gene expression [GO:0010468],
negative regulation of autophagy [GO:0010507],
positive regulation of gene expression [GO:0010628],
positive regulation of mitochondrion organization [GO:0010822],
osteoclast differentiation [GO:0030316],
regulation of TOR signaling [GO:0032006],
positive regulation of TOR signaling [GO:0032008],
detection of lipopolysaccharide [GO:0032497],
detection of peptidoglycan [GO:0032499],
regulation of interleukin-6 production [GO:0032675],
negative regulation of interleukin-1 beta production [GO:0032691],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of macrophage fusion [GO:0034241],
defense response to bacterium [GO:0042742],
negative regulation of apoptotic process [GO:0043066],
apoptotic cell clearance [GO:0043277],
innate immune response [GO:0045087],
regulation of innate immune response [GO:0045088],
positive regulation of osteoclast differentiation [GO:0045672],
astrocyte activation [GO:0048143],
positive regulation of protein secretion [GO:0050714],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
regulation of immune response [GO:0050776],
positive regulation of calcium-mediated signaling [GO:0050850],
positive regulation of chemotaxis [GO:0050921],
regulation of resting membrane potential [GO:0060075],
positive regulation of phagocytosis, engulfment [GO:0060100],
microglial cell proliferation [GO:0061518],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
detection of lipoteichoic acid [GO:0070392],
cellular response to lipoteichoic acid [GO:0071223],
cellular response to peptidoglycan [GO:0071224],
regulation of macrophage inflammatory protein 1 alpha production [GO:0071640],
dendritic cell differentiation [GO:0097028],
beta-amyloid clearance [GO:0097242],
import into cell [GO:0098657],
positive regulation of beta-amyloid clearance [GO:1900223],
positive regulation of engulfment of apoptotic cell [GO:1901076],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of proteasomal protein catabolic process [GO:1901800],
positive regulation of inward rectifier potassium channel activity [GO:1901980],
regulation of intracellular signal transduction [GO:1902531],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of C-C chemokine receptor CCR7 signaling pathway [GO:1903082],
positive regulation of microglial cell activation [GO:1903980],
negative regulation of autophagic cell death [GO:1904093],
positive regulation of microglial cell migration [GO:1904141],
cellular response to beta-amyloid [GO:1904646],
positive regulation of CAMKK-AMPK signaling cascade [GO:1905291],
positive regulation of CD40 signaling pathway [GO:2000350],
positive regulation of ATP biosynthetic process [GO:2001171],
lipopolysaccharide-mediated signaling pathway [GO:0031663],

Molecular Function:
lipopolysaccharide binding [GO:0001530],
beta-amyloid binding [GO:0001540],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
high-density lipoprotein particle binding [GO:0008035],
lipid binding [GO:0008289],
low-density lipoprotein particle binding [GO:0030169],
apolipoprotein binding [GO:0034185],
apolipoprotein A-I binding [GO:0034186],
very-low-density lipoprotein particle binding [GO:0034189],
signaling receptor activity [GO:0038023],
peptidoglycan binding [GO:0042834],
macromolecular complex binding [GO:0044877],
lipoteichoic acid binding [GO:0070891],
lipoprotein particle binding [GO:0071813],
scaffold protein binding [GO:0097110],
protein tyrosine kinase binding [GO:1990782],
transmembrane signaling receptor activity [GO:0004888],

Cellular Component:
extracellular region [GO:0005576],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
integral component of membrane [GO:0016021],
intrinsic component of plasma membrane [GO:0031226],
membrane [GO:0016020],