TRAF6

TNF receptor associated factor 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31428639 Primary stem cells derived from bone marrow Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32100342 MCF 10A Human NO
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord Human No
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord rat No

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
activation of MAPK activity [GO:0000187],
protein polyubiquitination [GO:0000209],
ossification [GO:0001503],
in utero embryonic development [GO:0001701],
neural tube closure [GO:0001843],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
toll-like receptor signaling pathway [GO:0002224],
positive regulation of T cell cytokine production [GO:0002726],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
cellular response to DNA damage stimulus [GO:0006974],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
JNK cascade [GO:0007254],
protein deubiquitination [GO:0016579],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
osteoclast differentiation [GO:0030316],
membrane protein intracellular domain proteolysis [GO:0031293],
positive regulation of protein ubiquitination [GO:0031398],
positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666],
activation of protein kinase activity [GO:0032147],
positive regulation of interleukin-2 production [GO:0032743],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
toll-like receptor 9 signaling pathway [GO:0034162],
Fc-epsilon receptor signaling pathway [GO:0038095],
T-helper 1 type immune response [GO:0042088],
positive regulation of T cell proliferation [GO:0042102],
odontogenesis of dentin-containing tooth [GO:0042475],
myeloid dendritic cell differentiation [GO:0043011],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of interleukin-12 biosynthetic process [GO:0045084],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
bone resorption [GO:0045453],
positive regulation of osteoclast differentiation [GO:0045672],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
cell development [GO:0048468],
positive regulation of smooth muscle cell proliferation [GO:0048661],
T cell receptor signaling pathway [GO:0050852],
regulation of immunoglobulin secretion [GO:0051023],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
protein autoubiquitination [GO:0051865],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
protein K63-linked ubiquitination [GO:0070534],
response to interleukin-1 [GO:0070555],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to cytokine stimulus [GO:0071345],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996],
positive regulation of transcription regulatory region DNA binding [GO:2000679],
immune system process [GO:0002376],
immune response [GO:0006955],
signal transduction [GO:0007165],
animal organ morphogenesis [GO:0009887],
protein ubiquitination [GO:0016567],
cytokine-mediated signaling pathway [GO:0019221],
regulation of apoptotic process [GO:0042981],
bone remodeling [GO:0046849],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
tumor necrosis factor receptor binding [GO:0005164],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
protein kinase binding [GO:0019901],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],
ubiquitin conjugating enzyme binding [GO:0031624],
ubiquitin protein ligase binding [GO:0031625],
thioesterase binding [GO:0031996],
identical protein binding [GO:0042802],
histone deacetylase binding [GO:0042826],
protein kinase B binding [GO:0043422],
protein N-terminus binding [GO:0047485],
ubiquitin protein ligase activity [GO:0061630],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lipid particle [GO:0005811],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
cytoplasmic side of plasma membrane [GO:0009898],
endosome membrane [GO:0010008],
macromolecular complex [GO:0032991],
CD40 receptor complex [GO:0035631],
perinuclear region of cytoplasm [GO:0048471],
plasma membrane receptor complex [GO:0098802],