TNF receptor associated factor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
apoptotic process [GO:0006915],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
respiratory gaseous exchange [GO:0007585],
respiratory tube development [GO:0030323],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
regulation of apoptotic process [GO:0042981],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
positive regulation of protein kinase activity [GO:0045860],
positive regulation of JNK cascade [GO:0046330],
protein K63-linked ubiquitination [GO:0070534],
signal transduction [GO:0007165],
multicellular organism development [GO:0007275],

Molecular Function:
tumor necrosis factor receptor binding [GO:0005164],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
thioesterase binding [GO:0031996],
identical protein binding [GO:0042802],
WW domain binding [GO:0050699],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
bicellular tight junction [GO:0005923],
perinuclear region of cytoplasm [GO:0048471],
plasma membrane receptor complex [GO:0098802],
membrane [GO:0016020],
cell junction [GO:0030054],