TNF receptor associated factor 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of cytokine production [GO:0001817],
toll-like receptor signaling pathway [GO:0002224],
apoptotic process [GO:0006915],
signal transduction [GO:0007165],
Toll signaling pathway [GO:0008063],
protein deubiquitination [GO:0016579],
regulation of proteolysis [GO:0030162],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
regulation of interferon-beta production [GO:0032648],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
TRIF-dependent toll-like receptor signaling pathway [GO:0035666],
regulation of apoptotic process [GO:0042981],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
innate immune response [GO:0045087],
positive regulation of JNK cascade [GO:0046330],
regulation of defense response to virus [GO:0050688],
protein K63-linked ubiquitination [GO:0070534],
immune system process [GO:0002376],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
tumor necrosis factor receptor binding [GO:0005164],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
ubiquitin protein ligase binding [GO:0031625],
thioesterase binding [GO:0031996],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
mitochondrion [GO:0005739],
endosome [GO:0005768],
cytosol [GO:0005829],
cytoplasmic side of plasma membrane [GO:0009898],
CD40 receptor complex [GO:0035631],
plasma membrane receptor complex [GO:0098802],
cytoplasm [GO:0005737],