TPM1

tropomyosin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31148378 MRC-5 Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES
31915373 Hheart_LA_VS healthy Cardiomyocyte Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
positive regulation of heart rate by epinephrine [GO:0003065],
muscle contraction [GO:0006936],
regulation of muscle contraction [GO:0006937],
cytoskeleton organization [GO:0007010],
actin filament organization [GO:0007015],
regulation of heart contraction [GO:0008016],
regulation of cell shape [GO:0008360],
muscle filament sliding [GO:0030049],
negative regulation of cell migration [GO:0030336],
ruffle organization [GO:0031529],
positive regulation of ATPase activity [GO:0032781],
cellular response to reactive oxygen species [GO:0034614],
wound healing [GO:0042060],
sarcomere organization [GO:0045214],
positive regulation of cell adhesion [GO:0045785],
positive regulation of stress fiber assembly [GO:0051496],
ventricular cardiac muscle tissue morphogenesis [GO:0055010],
cardiac muscle contraction [GO:0060048],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
negative regulation of vascular associated smooth muscle cell migration [GO:1904753],
embryo development [GO:0009790],
regulation of ATPase activity [GO:0043462],
actin filament capping [GO:0051693],

Molecular Function:
actin binding [GO:0003779],
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
cytoskeletal protein binding [GO:0008092],
structural constituent of muscle [GO:0008307],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
actin filament binding [GO:0051015],
protein N-terminus binding [GO:0047485],
disordered domain specific binding [GO:0097718],

Cellular Component:
stress fiber [GO:0001725],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
muscle thin filament tropomyosin [GO:0005862],
actin filament [GO:0005884],
actin cytoskeleton [GO:0015629],
sarcomere [GO:0030017],
bleb [GO:0032059],
ruffle membrane [GO:0032587],
cytoplasm [GO:0005737],
myofibril [GO:0030016],
macromolecular complex [GO:0032991],