BTG2
BTG anti-proliferation factor 2
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 26568417 | Primary progenitor cells derived from mesoderma | Interdigit limbs, Explants | Mouse, avian, duck | NO |
| 27545311 | U2OS | Human | YES | |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 29548335 | Saos-2 | Human | YES | |
| 30967634 | HUVEC | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
| 32042076 | Primary fibroblasts derived from skin | Human | YES | |
| 32098270 | HUVEC | Human | NO | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 27208501 | EJ | Human | NO | |
| 27932314 | Huh7 | Human | NO | |
GO terms:
Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
DNA repair [GO:0006281],
protein methylation [GO:0006479],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
negative regulation of cell proliferation [GO:0008285],
associative learning [GO:0008306],
response to mechanical stimulus [GO:0009612],
anterior/posterior pattern specification [GO:0009952],
response to organic cyclic compound [GO:0014070],
negative regulation of translation [GO:0017148],
dentate gyrus development [GO:0021542],
central nervous system neuron development [GO:0021954],
neuron projection development [GO:0031175],
skeletal muscle cell differentiation [GO:0035914],
response to peptide hormone [GO:0043434],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of mitotic cell cycle [GO:0045930],
response to electrical stimulus [GO:0051602],
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213],
negative regulation of neural precursor cell proliferation [GO:2000178],
neuron differentiation [GO:0030182],
negative regulation of apoptotic process [GO:0043066],
Molecular Function:
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
protein binding [GO:0005515],
Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],