BTG2

BTG anti-proliferation factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26568417 Primary progenitor cells derived from mesoderma Interdigit limbs, Explants Mouse, avian, duck NO
27545311 U2OS Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
30967634 HUVEC Human YES
31945125 Primary astrocytes derived from brain Human YES
32042076 Primary fibroblasts derived from skin Human YES
32098270 HUVEC Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27208501 EJ Human NO
27932314 Huh7 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
DNA repair [GO:0006281],
protein methylation [GO:0006479],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
negative regulation of cell proliferation [GO:0008285],
associative learning [GO:0008306],
response to mechanical stimulus [GO:0009612],
anterior/posterior pattern specification [GO:0009952],
response to organic cyclic compound [GO:0014070],
negative regulation of translation [GO:0017148],
dentate gyrus development [GO:0021542],
central nervous system neuron development [GO:0021954],
neuron projection development [GO:0031175],
skeletal muscle cell differentiation [GO:0035914],
response to peptide hormone [GO:0043434],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of mitotic cell cycle [GO:0045930],
response to electrical stimulus [GO:0051602],
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213],
negative regulation of neural precursor cell proliferation [GO:2000178],
neuron differentiation [GO:0030182],
negative regulation of apoptotic process [GO:0043066],

Molecular Function:
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],