TP53

tumor protein p53

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
10805721 MEF, pro-B-cell lymphoma cells Mouse NO
11106750 Primary MEF Head, Liver Mouse NO
11914273 MEFs, U2OS, HEK, human B cells Human, mouse NO
11971980 MEF Mouse NO
12077343 R2F, HM3, OKF4, HuCL-22, ConjEp-1, K17, POE9n, N/E6E7, MEFs Human, mouse NO
12080348 MEFs, U2OS, Phoenix, WI-38 Human, mouse NO
12101184 MCF7, MDA-MB-231 Mouse NO
12533509 MEF Embryos Mouse NO
12551891 MEF, primary striatum cells, 293T Mouse NO
12629205 MEF Mouse NO
14612402 EJ, PC3, HCT116, 293T cells, MEF Human, mouse NO
15156563 MEF Mouse NO
15302571 Primary fetal bovine fibroblasts Bovine NO
15606307 Human NO
15616590 IMR-90, LF1 , WI38, MEF Human, mouse NO
15711569 HVT, SM1 Human NO
15753076 Primary hematopoietic progenitor cells Mouse NO
16079796 Primary fibroblasts Liver Mouse NO
16079851 MEF Prostate gland Human, mouse NO
16123778 C6D1 Rat NO
16171786 BJ, U87MG Human NO
16209708 Primary normal human fibroblast derived from neonatal foreskin Human NO
16243918 HUVEC Human NO
16339764 EPC Human NO
16436515 IMR-90, TSP, MEF Human, mouse NO
16513254 BJ, IMR-90, primary mouse astrocytes, MEF Human, mouse NO
16813656 SC-2 Avian NO
16951143 Primary normal human fibroblasts Human NO
17012228 HEK293, MEF Human, mouse NO
17014852 MRC-5, WI-38 Human NO
17136094 BJ, HMEC Human NO
17172844 MEF, ES Human, mouse NO
17332504 HeLa, MEF, NB4, WI-38, H1299, U2OS Human, mouse NO
17396137 MEF Lung, Kidney, Liver,Spleen, Small intestine Mouse NO
17452980 H1299, U2OS, MECs Human NO
17460193 U2OS Human NO
17488820 293FT, Phoenix amphotropic, WI-38, IMR-90 Human NO
17576930 Primary cells derived from melanoma Mouse NO
17662641 A549 Human NO
17721438 IMR-90, WI-38 Human NO
17804819 HUVEC, HDF, MEF Artery Human, mouse NO
17902269 Kidney Mouse NO
18056407 BJ, Saos-2, U2OS, IIICF/A2, SUSM-1, GM847 SV4, HeLa, MCF7 Human NO
18089808 HCT116, MCF1A, MCF-7, DU-145 Human NO
18216268 MEF Mouse NO
18216278 Primary keratinocytes Human NO
18425358 Primary skin fibroblasts Human NO
18451145 GM842, NHF-hTERT, RKO, LS174T, SW62, WiDr, A549, NCI-H157, NCI-H1299, Calu-6, MCF7,U2OS,IMR-90, MRC-5,WI-38, HCT116 Human NO
18512237 PC3, MCF-7, MEF Human, mouse NO
18591425 MEF Embryos, Skin Mouse NO
18662989 NHP, mouse stem cells Prostate gland Human, mouse NO
18691182 MDAH41, IMR-90 Human NO
18852884 Primary foreskin fibroblasts Human NO
18948382 PHLFs Human NO
18974396 WI-38, IMR-90, BJ, Saos-2 Human NO
19001376 HeLa, U2OS, MDA-MB-435, TIG-1, MRC5 Human NO
19011633 MEF Mouse NO
19015633 HeLa, Caski, Siha, C33A, H1299 Human NO
19048622 Breast Human, mouse NO
19071156 EBM-2, HUVEC, MEF Umbilical vein Human, mouse NO
19082758 IMR-90 Human NO
19141477 Primary fibroblasts derived from skin Human NO
19197340 IMR-90, GP293, WI-38, Human NO
19308294 MSC Fibrous connective Mouse NO
19377286 PC3 Human NO
19389934 Primary human melanocytes Epidermis Human, mouse NO
19396980 MEF Spleen, Liver, Kidney Mouse NO
19434633 LNCaP, RWPE-1, BJ HDFs Human NO
19701195 MDAH41, WI38, MRC-5, H1299 Colon Human NO
19718037 Adipose Mouse NO
19855935 Human NO
19935700 Spleens, Lymph nodes, Thymus Mouse NO
20018721 Primary cells derived from pancreas Pancreas Human, mouse NO
20118236 MEF, HUF Mouse NO
20124728 Uterus, Decidual Mouse NO
20157537 WMM1175 melanoma cells, U2OS, HEMs,MEF Human, mouse NO
20160010 TIG3, HeLa, Phoenix Human NO
20228809 H1299, MCF1, MCF7, U2OS, BJ Human NO
20452981 IMR-90, BJ-1 Human NO
20606252 HT-p21-9, RPE, MEF Mouse NO
20660729 BJ, primary epithelial cells, HCT116, 293T Human NO
20720180 HK-2 Kidney,Renal tubules Rat NO
20969773 MCF7, Bovine Mammary Epithelial Cells (BMEC) Mammary gland Human, bovine NO
21331045 Colon Human NO
21535365 IMR-90 Human NO
21678067 C85 Human NO
21695255 Mel-1 , Mel-9, MEF Human, mouse NO
21699781 Rb/K343, K1, K2 Pancreas Mouse NO
21764855 RKO, MCF7, HCT116, H1299,SW48, MEF Lymph nodes Human, mouse, scrofa NO
21968188 HCT116, HEK 293 Human NO
21973212 MRC-5 Human NO
22012588 HeLa, A549, WI-38 Human NO
22024481 HDFs, HUVEC, EBM‐2 Human NO
22052190 Primary vascular endothelial cells Aorta Human, mouse NO
22090360 WSU-HN30 Human NO
22217266 Primary glomerular mesangial cells Human NO
22431922 MEFs, U373MG, H1299 Human, mouse NO
22750558 MRC-5 Lung Human NO
22777358 MRC-5, WI-38, HEK 293, primary fibroblasts Human, mouse NO
22802529 IMR-90, WI-38, MEF Human, mouse NO
22904680 LAN-1 Human NO
23291986 HepG2, Hep3B, Mahlavu, SK-HEP-1 Human NO
23401567 GM18366, AG6234, AG13152, AG1649, AG5229 Human NO
23423975 Primary cells derived from hair follicle bulge, primary epidermal cells Epidermis Mouse NO
23448364 MEF, primary hepatocytes Thymus, Lung, Heart, Liver Mouse NO
23449538 Saos-2 Human NO
23478443 Primary human fibroblasts Human NO
23525475 Primary dermal fibroblasts, HUVEC Human NO
23555779 NHM, VHM Skin Human NO
23562644 HSC, BMDM, primary sorted macrophages, Kupffer cells Liver Mouse NO
23578831 Primary fibroblasts, primary cells derived from dermal papillae Skin Human NO
23649808 HCA2, BJ , IMR-90, WI-38, IMR-901, AT2SF, AT5823, primary epithelial cells, primary cells derived from prostate gland, MEFs Human, mouse NO
23683497 A549 H46, H1299 Human NO
23727633 Primary tenocytes Human NO
23811199 MEF Mouse NO
23832324 VSMC Human, mouse NO
23869868 U2OS, Saos‐2 , LLC, MCF7, primary fibroblasts, MSF Human, mouse NO
23940580 Kidney Mouse NO
23966171 MCF7, HEK 293, BSC4, H1299, MEF Human, mouse NO
24009740 Primary cells derived from bone marrow, primary osteoblast-like stromal cells Mouse NO
24040275 Primary cardiac fibroblasts Mouse NO
24043758 Primary cells derived from liver carcinoma ` Human NO
24130040 Primary BM-MSC Human NO
24151513 Primary BM-MSC Human NO
24231352 Primary lymphocytes derived from blood Human NO
24445528 Primary fibroblasts Human NO
24651677 Primary cells derived from aorta Aorta Mouse NO
24990949 Primary fibroblasts Human NO
25070626 U2OS, MCF7, IMR-90, HCT116, A549, MEF Human, mouse NO
25149358 BJ, MEF Brain Human, mouse NO
25193859 Primary cells derived from colorectal cancer Human NO
25253740 Primary cells derived from mammary epithelium Glands Mouse NO
25367309 HDF, HEK 293T, HCT116 Human NO
25382750 HMEC, MRC5, Lovo, MKN28, MKN45, KATOIII, NCI-N87, SNU-1, SNU-16, SGC-791, AGS Gastric Human NO
25464270 NHFs Human NO
25785833 Primary human dermal fibroblasts (HDF) Human NO
26225749 MCF7, MDA-MB-231 Human NO
26309394 NOZ, GBC-SD, SGC-996, EHGB-1, EH-GB-2 Human, mouse NO
26477313 BVE–ATC-c1, BVE–ATC-c2, primary normal thyroid culture, BVE–PTC, ATCs Thymus Mouse NO
26503169 Primary Pax7+ cells,satelite, macrophages Muscle Mouse NO
26511486 Prostate gland Mouse NO
26598601 Pineal cells, MEF, HEK 293T Neuroectoderm Mouse NO
26820992 MCF1A Human NO
26904954 IMR-90, HEK 293T, U2OS, PANC-1 Human NO
27016071 Primary fibroblasts Human NO
27050276 MHM, U2OS, S4 Human NO
27129219 H1299, A549, HepG2, U2OS, HEK293T, WI-38 Human NO
27238838 MEF Mouse NO
27468691 LX-2, HSC Mouse NO
27533246 U87MG Human NO
27653035 Primary mesenchymal stem cells Placenta Human NO
27664376 Primary β cells derived from pancreas Pancreas Mouse NO
27698449 L-2 Human NO
27702651 A375, 293A, 293T, 293FT, B16, A259, HeLa, U87 Human NO
27703600 BMSCs Femurs and tibias Rat NO
27721459 HSC, primary HSC Liver Human, rodents NO
27836734 NCI-H292 Human NO
28165661 Saos-2 Human NO
28182012 SW48, LoVo, SW48, HCT116, KM12, HT29 Human NO
28277545 Primary skin fibroblasts Human NO
28431961 HMVEC-L Human NO
28486108 APL, NB4, BM Human, mouse NO
28613007 TM3, HEK 293T TestIs Mouse NO
28626028 HUVEC, EC Human, mouse NO
28691365 HNSCC, EJ, H1299, WI-38 Human NO
28745322 Lung Mouse NO
29039595 Primary cells derived from intervertebral disc Intervertebral disc, Lumbar spines Rat NO
29356545 293T, U87, HepG2 Kidney, Glioma, Liver Human NO
29362483 Heart Mouse NO
29392777 OPC Brain Mouse NO
29525471 Primary epidermal melanocytes Human NO
29590616 Lung Mouse NO
29700214 NPCs Cartilage Rat NO
29875661 A549, H1298 Lung Human, mouse NO
29891592 HUVEC Human, mouse NO
30341510 HGMC Human NO
30977425 Primary mononuclear cells derived from blood Rat NO
30997718 B16-F10 Mouse NO
30998584 Brain Mouse NO
31002926 Primary cells derived from intervertebral disc Human NO
31004310 Primary mononuclear cells derived from blood Human NO
31026379 Primary chondrocytes derived from cartilage Human NO
31059057 OVCA429 Human NO
31089945 HGMC Human NO
31091306 Primary Schwann cells derived spinal cord Mouse NO
31103748 A549 Human NO
31122700 Primary mesenchymal stromal cells derived from umbilical cord Human NO
31144244 Primary fibroblasts derived from skin Human NO
31148378 MRC-5 Human
31158660 Primary endothelial cells derived from artery Pig NO
31162503 Primary endothelial cells derived from umbilical vein Human NO
31424120 Placenta Mouse NO
31428639 Primary stem cells derived from bone marrow Human NO
31431479 B16-F1 Human NO
31439890 NCI-H1299 Human NO
31447100 Primary fibroblasts derived from skin Human NO
31469894 Cornea Mouse NO
31471533 Primary cells derived from nucleus pulposus Rat NO
31503005 MEF Mouse NO
31503007 SMMC-7721, Hep G2 Human NO
31513781 HBMEC Human NO
31517418 Hep G2 Human NO
31534052 Kidney Mouse YES
31545515 Human NO
31639393 MKN28, MKN45 Human NO
31646730 Primary epithelial cell derived from lung Pulmonary Fibrosis mice induced by BLM (bleyomycin) Mouse NO
31667457 Primary mesenchymal cells derived from bone Bone Mice NO
31752013 HUVEC Human NO
31752674 Primary mesenchymal cells derived from bone Rat NO
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31860636 2BS, 293T  Human YES
32026570 Muscle Rat NO
31227697 Primary mesenchymal progenitor cells derived from adipose tissue, primary stromal vascular cells derived from adipose tissue Human NO
32005663 MCF7, HCT 116 Human NO
32788068 VSMC Human NO
32304210 Primary cells derived from adipose tissue Human NO
32634429 Primary mesenchymal cells derived from adipose tissue Human NO
33495462 SW 1353 Human No
32521275 HeLa S3 Human No
31942817 Hep G2 Human No
32976914 Primary fibroblasts derived from skin Human No
32991815 Primary alveolar type II cells derived from lung Human NO
31792920 HUVEC Human NO
32652764 HCT 116 Human NO
32346137 HUVEC Artery Human NO
33184359 HDF Liver, skin, kidney, spleen, liver Human No
33146634 Primary cells derived from muscle Artery Human No
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord Human No
33184359 HDF Liver, skin, kidney, spleen, liver mouse No
33146634 Primary cells derived from muscle Artery mouse No
32781064 Primary cells derived form heart Mouse NO
32651107 Endometrium Mouse NO
33038325 Primary neurons derived from brain Mouse No
33320092 Primary adipocytes derived from epididymal fat tissue Mouse No
32527988 Intervertebral disc Mouse NO
32839595 MEF Mouse NO
33154378 Primary mesenchymal stem cells derived from bone Mouse NO
32439975 ARPE-19 Retina Mouse NO
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord rat No
32068317 F111 Rat NO
32997729 VSMC Rat NO
32753470 Rat2 Rat No
32952639 Primary chondrocyte derived from cartilage Rat NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20457898 HT-p21-9, WI-38 Human NO
23287532 PA-1 t Human NO
25144556 MRC-5, WI-38 Human NO
25369834 CT116, Primary cells derived from colorectal carcinoma Human NO
26138448 Primary normal human keratinocytes Human NO
28525591 Primary cells derived from uterus Uterus Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29429991 Primary fibroblast derived fom Hutchinson-Gilford Progeria Syndrome patients Human NO
31642042 HDF Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
DNA strand renaturation [GO:0000733],
in utero embryonic development [GO:0001701],
somitogenesis [GO:0001756],
release of cytochrome c from mitochondria [GO:0001836],
hematopoietic progenitor cell differentiation [GO:0002244],
T cell proliferation involved in immune response [GO:0002309],
B cell lineage commitment [GO:0002326],
T cell lineage commitment [GO:0002360],
response to ischemia [GO:0002931],
nucleotide-excision repair [GO:0006289],
double-strand break repair [GO:0006302],
regulation of transcription, DNA-templated [GO:0006355],
protein import into nucleus [GO:0006606],
autophagy [GO:0006914],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978],
ER overload response [GO:0006983],
cell cycle arrest [GO:0007050],
transforming growth factor beta receptor signaling pathway [GO:0007179],
Ras protein signal transduction [GO:0007265],
gastrulation [GO:0007369],
negative regulation of neuroblast proliferation [GO:0007406],
cell aging [GO:0007569],
protein localization [GO:0008104],
negative regulation of DNA replication [GO:0008156],
negative regulation of cell proliferation [GO:0008285],
determination of adult lifespan [GO:0008340],
mRNA transcription [GO:0009299],
rRNA transcription [GO:0009303],
response to salt stress [GO:0009651],
response to X-ray [GO:0010165],
response to gamma radiation [GO:0010332],
positive regulation of gene expression [GO:0010628],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
viral process [GO:0016032],
protein deubiquitination [GO:0016579],
cytokine-mediated signaling pathway [GO:0019221],
cerebellum development [GO:0021549],
negative regulation of cell growth [GO:0030308],
DNA damage response, signal transduction by p53 class mediator [GO:0030330],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
positive regulation of histone deacetylation [GO:0031065],
chromatin assembly [GO:0031497],
mitotic G1 DNA damage checkpoint [GO:0031571],
T cell differentiation in thymus [GO:0033077],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
regulation of tissue remodeling [GO:0034103],
cellular response to UV [GO:0034644],
multicellular organism growth [GO:0035264],
cellular response to drug [GO:0035690],
positive regulation of mitochondrial membrane permeability [GO:0035794],
positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003],
cellular response to glucose starvation [GO:0042149],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
entrainment of circadian clock by photoperiod [GO:0043153],
mitochondrial DNA repair [GO:0043504],
regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516],
positive regulation of neuron apoptotic process [GO:0043525],
negative regulation of proteolysis [GO:0045861],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
response to antibiotic [GO:0046677],
positive regulation of protein export from nucleus [GO:0046827],
negative regulation of fibroblast proliferation [GO:0048147],
circadian behavior [GO:0048512],
bone marrow development [GO:0048539],
embryonic organ development [GO:0048568],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
protein stabilization [GO:0050821],
negative regulation of helicase activity [GO:0051097],
RNA polymerase II transcriptional preinitiation complex assembly [GO:0051123],
protein tetramerization [GO:0051262],
neuron apoptotic process [GO:0051402],
negative regulation of telomerase activity [GO:0051974],
hematopoietic stem cell differentiation [GO:0060218],
interferon-gamma-mediated signaling pathway [GO:0060333],
cardiac septum morphogenesis [GO:0060411],
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419],
macromolecular complex assembly [GO:0065003],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
positive regulation of thymocyte apoptotic process [GO:0070245],
necroptotic process [GO:0070266],
positive regulation of cell cycle arrest [GO:0071158],
cellular response to hypoxia [GO:0071456],
cellular response to ionizing radiation [GO:0071479],
cellular response to gamma radiation [GO:0071480],
cellular response to UV-C [GO:0071494],
mitotic cell cycle arrest [GO:0071850],
signal transduction by p53 class mediator [GO:0072331],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
cellular response to actinomycin D [GO:0072717],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
positive regulation of cell aging [GO:0090343],
replicative senescence [GO:0090399],
oxidative stress-induced premature senescence [GO:0090403],
intrinsic apoptotic signaling pathway [GO:0097193],
oligodendrocyte apoptotic process [GO:0097252],
positive regulation of execution phase of apoptosis [GO:1900119],
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740],
negative regulation of macromitophagy [GO:1901525],
regulation of signal transduction by p53 class mediator [GO:1901796],
regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108],
regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902253],
regulation of cell cycle G2/M phase transition [GO:1902749],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024],
intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144],
regulation of transcription from RNA polymerase II promoter in response to DNA damage [GO:1990248],
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440],
regulation of fibroblast apoptotic process [GO:2000269],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
regulation of cellular senescence [GO:2000772],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
core promoter sequence-specific DNA binding [GO:0001046],
RNA polymerase II transcription factor binding [GO:0001085],
TFIID-class transcription factor binding [GO:0001094],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
protease binding [GO:0002020],
p53 binding [GO:0002039],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
mRNA 3'-UTR binding [GO:0003730],
copper ion binding [GO:0005507],
protein binding [GO:0005515],
ATP binding [GO:0005524],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
receptor tyrosine kinase binding [GO:0030971],
ubiquitin protein ligase binding [GO:0031625],
histone deacetylase regulator activity [GO:0035033],
histone acetyltransferase binding [GO:0035035],
identical protein binding [GO:0042802],
histone deacetylase binding [GO:0042826],
protein self-association [GO:0043621],
protein heterodimerization activity [GO:0046982],
protein N-terminus binding [GO:0047485],
chaperone binding [GO:0051087],
protein phosphatase 2A binding [GO:0051721],
MDM2/MDM4 family protein binding [GO:0097371],
disordered domain specific binding [GO:0097718],
promoter-specific chromatin binding [GO:1990841],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
replication fork [GO:0005657],
transcription factor complex [GO:0005667],
transcription factor TFIID complex [GO:0005669],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
endoplasmic reticulum [GO:0005783],
centrosome [GO:0005813],
cytosol [GO:0005829],
nuclear matrix [GO:0016363],
nuclear body [GO:0016604],
PML body [GO:0016605],
nuclear membrane [GO:0031965],
macromolecular complex [GO:0032991],
site of double-strand break [GO:0035861],