DNA topoisomerase II alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
30626320 HBEC Human NO
30977188 MSC Human YES
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31103748 A549 Human YES
31945125 Primary astrocytes derived from brain Human YES
32042076 Primary fibroblasts derived from skin Human YES

GO terms:

Biological Process:
resolution of meiotic recombination intermediates [GO:0000712],
sister chromatid segregation [GO:0000819],
hematopoietic progenitor cell differentiation [GO:0002244],
DNA topological change [GO:0006265],
DNA ligation [GO:0006266],
cellular response to DNA damage stimulus [GO:0006974],
chromosome segregation [GO:0007059],
female meiotic division [GO:0007143],
apoptotic chromosome condensation [GO:0030263],
embryonic cleavage [GO:0040016],
regulation of circadian rhythm [GO:0042752],
positive regulation of apoptotic process [GO:0043065],
mitotic DNA integrity checkpoint [GO:0044774],
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
rhythmic process [GO:0048511],
negative regulation of DNA duplex unwinding [GO:1905463],
DNA metabolic process [GO:0006259],
chromosome condensation [GO:0030261],
female meiosis chromosome separation [GO:0051309],

Molecular Function:
magnesium ion binding [GO:0000287],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
RNA binding [GO:0003723],
DNA topoisomerase type II (ATP-hydrolyzing) activity [GO:0003918],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
DNA-dependent ATPase activity [GO:0008094],
drug binding [GO:0008144],
DNA binding, bending [GO:0008301],
enzyme binding [GO:0019899],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
ubiquitin binding [GO:0043130],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
DNA topoisomerase activity [GO:0003916],
isomerase activity [GO:0016853],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromosome [GO:0000228],
condensed chromosome [GO:0000793],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
centriole [GO:0005814],
DNA topoisomerase complex (ATP-hydrolyzing) [GO:0009330],
viral integration complex [GO:0019035],
macromolecular complex [GO:0032991],
ribonucleoprotein complex [GO:1990904],
chromosome, centromeric region [GO:0000775],