TLR9

toll like receptor 9

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24340043 Liver Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
toll-like receptor signaling pathway [GO:0002224],
response to molecule of bacterial origin [GO:0002237],
positive regulation of immunoglobulin production [GO:0002639],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
inflammatory response [GO:0006954],
immune response [GO:0006955],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
I-kappaB phosphorylation [GO:0007252],
positive regulation of gene expression [GO:0010628],
maintenance of gastrointestinal epithelium [GO:0030277],
positive regulation of B cell proliferation [GO:0030890],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
tumor necrosis factor production [GO:0032640],
negative regulation of interleukin-6 production [GO:0032715],
negative regulation of interleukin-8 production [GO:0032717],
positive regulation of chemokine production [GO:0032722],
positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725],
positive regulation of interferon-beta production [GO:0032728],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-18 production [GO:0032741],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of tumor necrosis factor production [GO:0032760],
negative regulation of toll-like receptor signaling pathway [GO:0034122],
positive regulation of toll-like receptor signaling pathway [GO:0034123],
toll-like receptor 9 signaling pathway [GO:0034162],
regulation of toll-like receptor 9 signaling pathway [GO:0034163],
defense response to bacterium [GO:0042742],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of interferon-gamma biosynthetic process [GO:0045078],
innate immune response [GO:0045087],
positive regulation of interferon-alpha biosynthetic process [GO:0045356],
positive regulation of interferon-beta biosynthetic process [GO:0045359],
positive regulation of interleukin-8 biosynthetic process [GO:0045416],
regulation of B cell differentiation [GO:0045577],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
regulation of cytokine secretion [GO:0050707],
positive regulation of inflammatory response [GO:0050729],
defense response to Gram-negative bacterium [GO:0050829],
positive regulation of B cell activation [GO:0050871],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
defense response to virus [GO:0051607],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
negative regulation of calcium-transporting ATPase activity [GO:1901895],
microglial cell activation [GO:0001774],
cytokine production [GO:0001816],
regulation of protein phosphorylation [GO:0001932],
activation of innate immune response [GO:0002218],
immune system process [GO:0002376],
regulation of dendritic cell cytokine production [GO:0002730],
signal transduction [GO:0007165],
response to virus [GO:0009615],
positive regulation of autophagy [GO:0010508],
positive regulation of toll-like receptor 9 signaling pathway [GO:0034165],
regulation of inflammatory response [GO:0050727],
regulation of B cell activation [GO:0050864],
cellular response to chloroquine [GO:1902350],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
interleukin-1 receptor binding [GO:0005149],
siRNA binding [GO:0035197],
pattern recognition receptor activity [GO:0038187],
protein homodimerization activity [GO:0042803],
unmethylated CpG binding [GO:0045322],
protein binding [GO:0005515],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
early phagosome [GO:0032009],
endolysosome [GO:0036019],
endolysosome membrane [GO:0036020],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
phagocytic vesicle [GO:0045335],