TLR4

toll like receptor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26135899 Primary stem cells derived from mesenchyma Human NO
28898202 Adipose Mouse NO
30118525 HDF Human NO
31727865 Primary mesenchymal cells derived from bone marrow, Hs-27A Human NO
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30790400 Primary endothelial cells derived from lung, HUVEC Lung Human, mouse NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
activation of innate immune response [GO:0002218],
toll-like receptor signaling pathway [GO:0002224],
B cell proliferation involved in immune response [GO:0002322],
nitric oxide production involved in inflammatory response [GO:0002537],
regulation of dendritic cell cytokine production [GO:0002730],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
MyD88-independent toll-like receptor signaling pathway [GO:0002756],
phagocytosis [GO:0006909],
inflammatory response [GO:0006954],
immune response [GO:0006955],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
I-kappaB phosphorylation [GO:0007252],
positive regulation of platelet activation [GO:0010572],
positive regulation of gene expression [GO:0010628],
positive regulation of keratinocyte proliferation [GO:0010838],
astrocyte development [GO:0014002],
detection of fungus [GO:0016046],
positive regulation of B cell proliferation [GO:0030890],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
response to lipopolysaccharide [GO:0032496],
detection of lipopolysaccharide [GO:0032497],
interferon-gamma production [GO:0032609],
negative regulation of interferon-gamma production [GO:0032689],
negative regulation of interleukin-17 production [GO:0032700],
negative regulation of interleukin-23 production [GO:0032707],
negative regulation of interleukin-6 production [GO:0032715],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of chemokine production [GO:0032722],
positive regulation of interferon-alpha production [GO:0032727],
positive regulation of interferon-beta production [GO:0032728],
positive regulation of interferon-gamma production [GO:0032729],
positive regulation of interleukin-1 production [GO:0032732],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of tumor necrosis factor production [GO:0032760],
negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128],
toll-like receptor 4 signaling pathway [GO:0034142],
TRIF-dependent toll-like receptor signaling pathway [GO:0035666],
T-helper 1 type immune response [GO:0042088],
macrophage activation [GO:0042116],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
defense response to bacterium [GO:0042742],
positive regulation of macrophage activation [GO:0043032],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of interleukin-12 biosynthetic process [GO:0045084],
innate immune response [GO:0045087],
positive regulation of MHC class II biosynthetic process [GO:0045348],
positive regulation of interferon-beta biosynthetic process [GO:0045359],
positive regulation of interleukin-8 biosynthetic process [GO:0045416],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
negative regulation of osteoclast differentiation [GO:0045671],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
interleukin-1 beta secretion [GO:0050702],
positive regulation of interleukin-1 beta secretion [GO:0050718],
positive regulation of inflammatory response [GO:0050729],
defense response to Gram-negative bacterium [GO:0050829],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
intestinal epithelial structure maintenance [GO:0060729],
positive regulation of macrophage cytokine production [GO:0060907],
necroptotic process [GO:0070266],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430],
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to lipoteichoic acid [GO:0071223],
cellular response to mechanical stimulus [GO:0071260],
cellular response to interferon-gamma [GO:0071346],
apoptotic signaling pathway [GO:0097190],
positive regulation of cytokine production involved in inflammatory response [GO:1900017],
positive regulation of NLRP3 inflammasome complex assembly [GO:1900227],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of oxidative stress-induced neuron death [GO:1903223],
positive regulation of reactive oxygen species biosynthetic process [GO:1903428],
positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974],
positive regulation of matrix metallopeptidase secretion [GO:1904466],
cellular response to beta-amyloid [GO:1904646],
positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343],
microglial cell activation [GO:0001774],
immune system process [GO:0002376],
innate immune response-activating signal transduction [GO:0002758],
leukotriene metabolic process [GO:0006691],
response to oxidative stress [GO:0006979],
signal transduction [GO:0007165],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
response to bacterium [GO:0009617],
positive regulation of stress-activated MAPK cascade [GO:0032874],
positive regulation of apoptotic process [GO:0043065],
positive regulation of DNA binding [GO:0043388],
positive regulation of interleukin-1 biosynthetic process [GO:0045362],
positive regulation of interleukin-13 biosynthetic process [GO:0045368],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
response to ethanol [GO:0045471],
mast cell activation [GO:0045576],
positive regulation of lymphocyte proliferation [GO:0050671],
regulation of inflammatory response [GO:0050727],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
detection of temperature stimulus involved in sensory perception of pain [GO:0050965],
detection of mechanical stimulus involved in sensory perception of pain [GO:0050966],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
regulation of sensory perception of pain [GO:0051930],
response to fatty acid [GO:0070542],
regulation of tumor necrosis factor secretion [GO:1904467],

Molecular Function:
lipopolysaccharide binding [GO:0001530],
beta-amyloid binding [GO:0001540],
lipopolysaccharide receptor activity [GO:0001875],
transmembrane signaling receptor activity [GO:0004888],
receptor binding [GO:0005102],
protein binding [GO:0005515],
signaling receptor activity [GO:0038023],
identical protein binding [GO:0042802],
protein heterodimerization activity [GO:0046982],
NAD(P)+ nucleosidase activity [GO:0050135],
hydrolase activity [GO:0016787],
phosphatidylinositol 3-kinase binding [GO:0043548],

Cellular Component:
ruffle [GO:0001726],
phagocytic cup [GO:0001891],
cytoplasm [GO:0005737],
early endosome [GO:0005769],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
endosome membrane [GO:0010008],
intrinsic component of plasma membrane [GO:0031226],
receptor complex [GO:0043235],
lipopolysaccharide receptor complex [GO:0046696],
perinuclear region of cytoplasm [GO:0048471],
endosome [GO:0005768],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell projection [GO:0042995],
membrane raft [GO:0045121],