TLR2

toll like receptor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
microglial cell activation [GO:0001774],
cell activation [GO:0001775],
toll-like receptor signaling pathway [GO:0002224],
cytokine secretion involved in immune response [GO:0002374],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
leukotriene metabolic process [GO:0006691],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
immune response [GO:0006955],
signal transduction [GO:0007165],
I-kappaB phosphorylation [GO:0007252],
learning [GO:0007612],
negative regulation of cell proliferation [GO:0008285],
response to toxic substance [GO:0009636],
positive regulation of gene expression [GO:0010628],
microglia development [GO:0014005],
positive regulation of Wnt signaling pathway [GO:0030177],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
central nervous system myelin formation [GO:0032289],
response to progesterone [GO:0032570],
interleukin-10 production [GO:0032613],
tumor necrosis factor production [GO:0032640],
positive regulation of chemokine production [GO:0032722],
positive regulation of interferon-beta production [GO:0032728],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-18 production [GO:0032741],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of tumor necrosis factor production [GO:0032760],
response to insulin [GO:0032868],
positive regulation of toll-like receptor signaling pathway [GO:0034123],
toll-like receptor 2 signaling pathway [GO:0034134],
toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123],
toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124],
detection of triacyl bacterial lipopeptide [GO:0042495],
detection of diacyl bacterial lipopeptide [GO:0042496],
neutrophil degranulation [GO:0043312],
innate immune response [GO:0045087],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
nitric oxide metabolic process [GO:0046209],
positive regulation of oligodendrocyte differentiation [GO:0048714],
positive regulation of inflammatory response [GO:0050729],
negative regulation of phagocytosis [GO:0050765],
defense response to Gram-positive bacterium [GO:0050830],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
negative regulation of synapse assembly [GO:0051964],
response to fatty acid [GO:0070542],
cellular response to bacterial lipopeptide [GO:0071221],
cellular response to lipoteichoic acid [GO:0071223],
cellular response to interferon-gamma [GO:0071346],
cellular response to diacyl bacterial lipopeptide [GO:0071726],
cellular response to triacyl bacterial lipopeptide [GO:0071727],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974],
positive regulation of matrix metallopeptidase secretion [GO:1904466],
positive regulation of interleukin-8 secretion [GO:2000484],
positive regulation of interleukin-6 secretion [GO:2000778],
response to molecule of bacterial origin [GO:0002237],
response to molecule of fungal origin [GO:0002238],
immune system process [GO:0002376],
positive regulation of leukocyte migration [GO:0002687],
regulation of dendritic cell cytokine production [GO:0002730],
cell surface pattern recognition receptor signaling pathway [GO:0002752],
defense response [GO:0006952],
response to bacterium [GO:0009617],
negative regulation of actin filament polymerization [GO:0030837],
response to bacterial lipoprotein [GO:0032493],
response to peptidoglycan [GO:0032494],
negative regulation of interleukin-12 production [GO:0032695],
negative regulation of interleukin-17 production [GO:0032700],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
regulation of cytokine secretion [GO:0050707],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of interleukin-1 beta secretion [GO:0050718],
induction by symbiont of defense-related host nitric oxide production [GO:0052063],
positive regulation of macrophage cytokine production [GO:0060907],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to peptidoglycan [GO:0071224],
positive regulation of xenophagy [GO:1904417],
positive regulation of tumor necrosis factor secretion [GO:1904469],

Molecular Function:
lipopolysaccharide binding [GO:0001530],
beta-amyloid binding [GO:0001540],
lipopolysaccharide receptor activity [GO:0001875],
protein binding [GO:0005515],
Toll-like receptor binding [GO:0035325],
signaling receptor activity [GO:0038023],
pattern recognition receptor activity [GO:0038187],
triacyl lipopeptide binding [GO:0042497],
identical protein binding [GO:0042802],
peptidoglycan binding [GO:0042834],
macromolecular complex binding [GO:0044877],
NAD(P)+ nucleosidase activity [GO:0050135],
hydrolase activity [GO:0016787],
diacyl lipopeptide binding [GO:0042498],
lipoteichoic acid binding [GO:0070891],
lipopeptide binding [GO:0071723],

Cellular Component:
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
secretory granule membrane [GO:0030667],
phagocytic vesicle membrane [GO:0030670],
intrinsic component of plasma membrane [GO:0031226],
Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354],
cell projection [GO:0042995],
cell body [GO:0044297],
membrane raft [GO:0045121],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cytoplasmic vesicle [GO:0031410],
Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355],