tolloid like 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
multicellular organism development [GO:0007275],
extracellular matrix disassembly [GO:0022617],
cell differentiation [GO:0030154],
negative regulation of skeletal muscle tissue growth [GO:0048632],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
calcium ion binding [GO:0005509],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],