tight junction protein 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31534052 Kidney Mouse NO

GO terms:

Biological Process:
homotypic cell-cell adhesion [GO:0034109],
hippo signaling [GO:0035329],
maintenance of blood-brain barrier [GO:0035633],
GMP metabolic process [GO:0046037],
GDP metabolic process [GO:0046710],
intestinal absorption [GO:0050892],
establishment of endothelial intestinal barrier [GO:0090557],
regulation of membrane permeability [GO:0090559],
TNFSF11-mediated signaling pathway [GO:0071847],
negative regulation of osteoclast development [GO:2001205],

Molecular Function:
guanylate kinase activity [GO:0004385],
protein binding [GO:0005515],
protein domain specific binding [GO:0019904],
protein binding, bridging [GO:0030674],
cadherin binding [GO:0045296],
protein tyrosine kinase binding [GO:1990782],
protein C-terminus binding [GO:0008022],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
bicellular tight junction [GO:0005923],
cell-cell contact zone [GO:0044291],
cell-cell junction [GO:0005911],
gap junction [GO:0005921],
cell surface [GO:0009986],
membrane [GO:0016020],
cell junction [GO:0030054],
occluding junction [GO:0070160],