tight junction protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31534052 MDCK Kidney Mouse, dog NO

GO terms:

Biological Process:
cell-cell junction assembly [GO:0007043],
positive regulation of cell migration [GO:0030335],
actomyosin structure organization [GO:0031032],
adherens junction maintenance [GO:0034334],
hippo signaling [GO:0035329],
maintenance of blood-brain barrier [GO:0035633],
cell-cell junction organization [GO:0045216],
regulation of cytoskeleton organization [GO:0051493],
negative regulation of stress fiber assembly [GO:0051497],
protein localization to adherens junction [GO:0071896],
establishment of endothelial intestinal barrier [GO:0090557],
regulation of cell junction assembly [GO:1901888],
protein localization to bicellular tight junction [GO:1902396],
positive regulation of sprouting angiogenesis [GO:1903672],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
negative regulation of actin cytoskeleton reorganization [GO:2000250],
regulation of bicellular tight junction assembly [GO:2000810],
blastocyst formation [GO:0001825],
sensory perception of sound [GO:0007605],

Molecular Function:
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
cadherin binding [GO:0045296],
protein C-terminus binding [GO:0008022],
protein domain specific binding [GO:0019904],
connexin binding [GO:0071253],

Cellular Component:
podosome [GO:0002102],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
gap junction [GO:0005921],
bicellular tight junction [GO:0005923],
basolateral plasma membrane [GO:0016323],
cell junction [GO:0030054],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
apical junction complex [GO:0043296],
apical part of cell [GO:0045177],
occluding junction [GO:0070160],
nucleus [GO:0005634],
cell-cell junction [GO:0005911],
cell surface [GO:0009986],
intercalated disc [GO:0014704],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
apicolateral plasma membrane [GO:0016327],
intercellular canaliculus [GO:0046581],