TIMP2

TIMP metallopeptidase inhibitor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
central nervous system development [GO:0007417],
aging [GO:0007568],
negative regulation of cell proliferation [GO:0008285],
response to hormone [GO:0009725],
response to organic substance [GO:0010033],
negative regulation of endopeptidase activity [GO:0010951],
extracellular matrix disassembly [GO:0022617],
regulation of Rap protein signal transduction [GO:0032487],
response to cytokine [GO:0034097],
response to drug [GO:0042493],
neutrophil degranulation [GO:0043312],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of adenylate cyclase activity [GO:0045762],
negative regulation of mitotic cell cycle [GO:0045930],
negative regulation of Ras protein signal transduction [GO:0046580],
negative regulation of membrane protein ectodomain proteolysis [GO:0051045],
negative regulation of metallopeptidase activity [GO:1905049],
negative regulation of peptidase activity [GO:0010466],
regulation of MAPK cascade [GO:0043408],
regulation of neuron differentiation [GO:0045664],
negative regulation of proteolysis [GO:0045861],
cellular response to organic substance [GO:0071310],

Molecular Function:
protease binding [GO:0002020],
integrin binding [GO:0005178],
protein binding [GO:0005515],
metalloendopeptidase inhibitor activity [GO:0008191],
zinc ion binding [GO:0008270],
peptidase inhibitor activity [GO:0030414],
enzyme inhibitor activity [GO:0004857],
enzyme activator activity [GO:0008047],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cell surface [GO:0009986],
growth cone [GO:0030426],
extracellular matrix [GO:0031012],
specific granule lumen [GO:0035580],
neuronal cell body [GO:0043025],
tertiary granule lumen [GO:1904724],
ficolin-1-rich granule lumen [GO:1904813],
basement membrane [GO:0005604],
neuron projection [GO:0043005],