TIMP1

TIMP metallopeptidase inhibitor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31208977 CAKI-1 Human NO
31219154 MCF10A Human YES
31687975 IMR-90 Human YES
31900795 Primary astrocytes derived from brain Mouse NO
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31602539 HDF Human NO

GO terms:

Biological Process:
cell activation [GO:0001775],
connective tissue replacement involved in inflammatory response wound healing [GO:0002248],
platelet degranulation [GO:0002576],
aging [GO:0007568],
positive regulation of cell proliferation [GO:0008284],
response to hormone [GO:0009725],
response to organic substance [GO:0010033],
negative regulation of endopeptidase activity [GO:0010951],
cytokine-mediated signaling pathway [GO:0019221],
extracellular matrix disassembly [GO:0022617],
response to cytokine [GO:0034097],
negative regulation of apoptotic process [GO:0043066],
negative regulation of catalytic activity [GO:0043086],
response to peptide hormone [GO:0043434],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
negative regulation of membrane protein ectodomain proteolysis [GO:0051045],
cartilage development [GO:0051216],
negative regulation of trophoblast cell migration [GO:1901164],
negative regulation of metallopeptidase activity [GO:1905049],
regulation of integrin-mediated signaling pathway [GO:2001044],
negative regulation of peptidase activity [GO:0010466],

Molecular Function:
protease binding [GO:0002020],
cytokine activity [GO:0005125],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
metalloendopeptidase inhibitor activity [GO:0008191],
zinc ion binding [GO:0008270],
peptidase inhibitor activity [GO:0030414],
enzyme inhibitor activity [GO:0004857],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
basement membrane [GO:0005604],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
extracellular matrix [GO:0031012],
platelet alpha granule lumen [GO:0031093],
extracellular exosome [GO:0070062],