TIMELESS

timeless circadian regulator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30100061 2BS, HEK293 Human NO
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA replication checkpoint [GO:0000076],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
morphogenesis of an epithelium [GO:0002009],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
circadian rhythm [GO:0007623],
detection of abiotic stimulus [GO:0009582],
lung development [GO:0030324],
regulation of cell proliferation [GO:0042127],
regulation of circadian rhythm [GO:0042752],
replication fork arrest [GO:0043111],
cell cycle phase transition [GO:0044770],
negative regulation of transcription, DNA-templated [GO:0045892],
replication fork protection [GO:0048478],
branching morphogenesis of an epithelial tube [GO:0048754],
cell division [GO:0051301],
cellular response to hydroxyurea [GO:0072711],
cellular response to cisplatin [GO:0072719],
cellular response to bleomycin [GO:1904976],
positive regulation of double-strand break repair via homologous recombination [GO:1905168],
positive regulation of double-strand break repair [GO:2000781],
branching involved in ureteric bud morphogenesis [GO:0001658],
kidney development [GO:0001822],
cell cycle [GO:0007049],
multicellular organism development [GO:0007275],
embryo development [GO:0009790],
positive regulation of circadian rhythm [GO:0042753],
rhythmic process [GO:0048511],

Molecular Function:
DNA binding [GO:0003677],
protein binding [GO:0005515],
identical protein binding [GO:0042802],

Cellular Component:
nuclear chromosome [GO:0000228],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
replication fork protection complex [GO:0031298],
site of double-strand break [GO:0035861],
chromosome [GO:0005694],