TIGAR

TP53 induced glycolysis regulatory phosphatase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA444 Skin, Lung Human YES

GO terms:

Biological Process:
response to ischemia [GO:0002931],
fructose 2,6-bisphosphate metabolic process [GO:0006003],
autophagy [GO:0006914],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],
response to xenobiotic stimulus [GO:0009410],
response to gamma radiation [GO:0010332],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
dephosphorylation [GO:0016311],
fructose 1,6-bisphosphate metabolic process [GO:0030388],
negative regulation of programmed cell death [GO:0043069],
regulation of pentose-phosphate shunt [GO:0043456],
positive regulation of DNA repair [GO:0045739],
negative regulation of glycolytic process [GO:0045820],
intestinal epithelial cell development [GO:0060576],
cellular response to cobalt ion [GO:0071279],
cellular response to hypoxia [GO:0071456],
negative regulation of neuron death [GO:1901215],
negative regulation of macromitophagy [GO:1901525],
regulation of response to DNA damage checkpoint signaling [GO:1902153],
positive regulation of hexokinase activity [GO:1903301],
negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
negative regulation of kinase activity [GO:0033673],

Molecular Function:
bisphosphoglycerate 2-phosphatase activity [GO:0004083],
fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331],
protein binding [GO:0005515],
catalytic activity [GO:0003824],
hydrolase activity [GO:0016787],

Cellular Component:
intracellular [GO:0005622],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
cytosol [GO:0005829],
mitochondrion [GO:0005739],