TIAM Rac1 associated GEF 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
signal transduction [GO:0007165],
small GTPase mediated signal transduction [GO:0007264],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
positive regulation of axonogenesis [GO:0050772],
activation of GTPase activity [GO:0090630],
G-protein coupled receptor signaling pathway [GO:0007186],
regulation of lipid metabolic process [GO:0019216],
positive regulation of apoptotic process [GO:0043065],
regulation of small GTPase mediated signal transduction [GO:0051056],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],

Cellular Component:
cytoplasm [GO:0005737],
membrane [GO:0016020],
cell projection [GO:0042995],
synapse [GO:0045202],
cytosol [GO:0005829],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
growth cone [GO:0030426],
perikaryon [GO:0043204],
extracellular exosome [GO:0070062],