TIAM1

TIAM Rac1 associated GEF 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
cardiac muscle hypertrophy [GO:0003300],
apoptotic process [GO:0006915],
cell-matrix adhesion [GO:0007160],
G-protein coupled receptor signaling pathway [GO:0007186],
small GTPase mediated signal transduction [GO:0007264],
positive regulation of cell proliferation [GO:0008284],
regulation of epithelial to mesenchymal transition [GO:0010717],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
cell migration [GO:0016477],
Rac protein signal transduction [GO:0016601],
positive regulation of cell migration [GO:0030335],
positive regulation of protein binding [GO:0032092],
cellular macromolecular complex assembly [GO:0034622],
response to cocaine [GO:0042220],
positive regulation of apoptotic process [GO:0043065],
positive regulation of JUN kinase activity [GO:0043507],
ephrin receptor signaling pathway [GO:0048013],
positive regulation of axonogenesis [GO:0050772],
regulation of small GTPase mediated signal transduction [GO:0051056],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
positive regulation of dendritic spine morphogenesis [GO:0061003],
regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178],
regulation of ERK1 and ERK2 cascade [GO:0070372],
protein localization to membrane [GO:0072657],
activation of GTPase activity [GO:0090630],
NMDA selective glutamate receptor signaling pathway [GO:0098989],
positive regulation of Schwann cell chemotaxis [GO:1904268],
regulation of dopaminergic neuron differentiation [GO:1904338],
regulation of modification of postsynaptic actin cytoskeleton [GO:1905274],
neuron projection extension [GO:1990138],
regulation of non-canonical Wnt signaling pathway [GO:2000050],
signal transduction [GO:0007165],
positive regulation of neuron projection development [GO:0010976],
brain-derived neurotrophic factor receptor signaling pathway [GO:0031547],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
regulation of GTPase activity [GO:0043087],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
lipid binding [GO:0008289],
kinase binding [GO:0019900],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
receptor tyrosine kinase binding [GO:0030971],
phospholipid binding [GO:0005543],
Ras GTPase binding [GO:0017016],
ephrin receptor binding [GO:0046875],
Rac GTPase binding [GO:0048365],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
membrane [GO:0016020],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
ruffle membrane [GO:0032587],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
cell-cell contact zone [GO:0044291],
axonal growth cone [GO:0044295],
main axon [GO:0044304],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],
pericentriolar material [GO:0000242],
cytoplasm [GO:0005737],
postsynaptic density [GO:0014069],
cell junction [GO:0030054],
somatodendritic compartment [GO:0036477],
kinocilium [GO:0060091],