THOP1

thimet oligopeptidase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
proteolysis [GO:0006508],
peptide metabolic process [GO:0006518],
intracellular signal transduction [GO:0035556],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
peptide binding [GO:0042277],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],

Cellular Component:
mitochondrial intermembrane space [GO:0005758],
cytosol [GO:0005829],
cytoplasm [GO:0005737],