THBS1

thrombospondin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
27607583 Primary cells derived from endothelium Mouse NO
29042481 HPAEC Lung Human, mouse NO
30814491 LS174T, MCF7, WI38 , 4TI Human NO
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31945125 Primary astrocytes derived from brain Human YES
31811565 Primary neurons cells derived from brain Brain Human, mouse, rat YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
33296652 heart heart Human NO
32972203 heartDPI14 vs healthy Endothelial cell Mouse NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
response to hypoxia [GO:0001666],
negative regulation of endothelial cell proliferation [GO:0001937],
negative regulation of cell-matrix adhesion [GO:0001953],
sprouting angiogenesis [GO:0002040],
chronic inflammatory response [GO:0002544],
platelet degranulation [GO:0002576],
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581],
negative regulation of dendritic cell antigen processing and presentation [GO:0002605],
inflammatory response [GO:0006954],
immune response [GO:0006955],
response to unfolded protein [GO:0006986],
cell cycle arrest [GO:0007050],
cell adhesion [GO:0007155],
positive regulation of cell proliferation [GO:0008284],
response to mechanical stimulus [GO:0009612],
response to glucose [GO:0009749],
positive regulation of endothelial cell migration [GO:0010595],
negative regulation of endothelial cell migration [GO:0010596],
negative regulation of plasma membrane long-chain fatty acid transport [GO:0010748],
negative regulation of nitric oxide mediated signal transduction [GO:0010751],
negative regulation of cGMP-mediated signaling [GO:0010754],
negative regulation of plasminogen activation [GO:0010757],
positive regulation of macrophage chemotaxis [GO:0010759],
positive regulation of fibroblast migration [GO:0010763],
cell migration [GO:0016477],
negative regulation of angiogenesis [GO:0016525],
peptide cross-linking [GO:0018149],
positive regulation of blood coagulation [GO:0030194],
extracellular matrix organization [GO:0030198],
positive regulation of cell migration [GO:0030335],
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511],
response to magnesium ion [GO:0032026],
response to progesterone [GO:0032570],
negative regulation of interleukin-12 production [GO:0032695],
positive regulation of transforming growth factor beta1 production [GO:0032914],
response to testosterone [GO:0033574],
cellular response to heat [GO:0034605],
response to endoplasmic reticulum stress [GO:0034976],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
positive regulation of phosphorylation [GO:0042327],
response to drug [GO:0042493],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
positive regulation of macrophage activation [GO:0043032],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
engulfment of apoptotic cell [GO:0043652],
regulation of megakaryocyte differentiation [GO:0045652],
positive regulation of translation [GO:0045727],
positive regulation of angiogenesis [GO:0045766],
behavioral response to pain [GO:0048266],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of chemotaxis [GO:0050921],
response to calcium ion [GO:0051592],
negative regulation of focal adhesion assembly [GO:0051895],
positive regulation of protein kinase B signaling [GO:0051897],
negative regulation of fibrinolysis [GO:0051918],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to growth factor stimulus [GO:0071363],
negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051],
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043],
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588],
negative regulation of sprouting angiogenesis [GO:1903671],
positive regulation of endothelial cell apoptotic process [GO:2000353],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
negative regulation of endothelial cell chemotaxis [GO:2001027],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
outflow tract morphogenesis [GO:0003151],
endocardial cushion development [GO:0003197],
growth plate cartilage development [GO:0003417],
positive regulation of cell-substrate adhesion [GO:0010811],
blood vessel morphogenesis [GO:0048514],
monocyte aggregation [GO:0070487],
positive regulation of transforming growth factor beta production [GO:0071636],
cellular response to nitric oxide [GO:0071732],

Molecular Function:
phosphatidylserine binding [GO:0001786],
fibronectin binding [GO:0001968],
integrin binding [GO:0005178],
extracellular matrix structural constituent [GO:0005201],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
heparin binding [GO:0008201],
fibroblast growth factor binding [GO:0017134],
low-density lipoprotein particle binding [GO:0030169],
identical protein binding [GO:0042802],
laminin binding [GO:0043236],
proteoglycan binding [GO:0043394],
transforming growth factor beta binding [GO:0050431],
fibrinogen binding [GO:0070051],
collagen V binding [GO:0070052],
extracellular matrix binding [GO:0050840],

Cellular Component:
extracellular region [GO:0005576],
fibrinogen complex [GO:0005577],
extracellular space [GO:0005615],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum lumen [GO:0005788],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
sarcoplasmic reticulum [GO:0016529],
secretory granule [GO:0030141],
extracellular matrix [GO:0031012],
platelet alpha granule [GO:0031091],
platelet alpha granule lumen [GO:0031093],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],