TGFBR1

transforming growth factor beta receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30790400 Primary endothelial cells derived from lung Mouse NO
31148378 MRC-5 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPKK activity [GO:0000186],
skeletal system development [GO:0001501],
in utero embryonic development [GO:0001701],
kidney development [GO:0001822],
blastocyst development [GO:0001824],
epithelial to mesenchymal transition [GO:0001837],
negative regulation of endothelial cell proliferation [GO:0001937],
positive regulation of endothelial cell proliferation [GO:0001938],
lens development in camera-type eye [GO:0002088],
ventricular trabecula myocardium morphogenesis [GO:0003222],
ventricular compact myocardium morphogenesis [GO:0003223],
proepicardium development [GO:0003342],
regulation of transcription, DNA-templated [GO:0006355],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
cell cycle arrest [GO:0007050],
signal transduction [GO:0007165],
transforming growth factor beta receptor signaling pathway [GO:0007179],
nervous system development [GO:0007399],
heart development [GO:0007507],
positive regulation of cell proliferation [GO:0008284],
germ cell migration [GO:0008354],
male gonad development [GO:0008584],
post-embryonic development [GO:0009791],
anterior/posterior pattern specification [GO:0009952],
positive regulation of gene expression [GO:0010628],
regulation of epithelial to mesenchymal transition [GO:0010717],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
protein deubiquitination [GO:0016579],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
collagen fibril organization [GO:0030199],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
regulation of protein ubiquitination [GO:0031396],
negative regulation of chondrocyte differentiation [GO:0032331],
activin receptor signaling pathway [GO:0032924],
intracellular signal transduction [GO:0035556],
wound healing [GO:0042060],
endothelial cell activation [GO:0042118],
extracellular structure organization [GO:0043062],
regulation of protein binding [GO:0043393],
endothelial cell migration [GO:0043542],
positive regulation of transcription, DNA-templated [GO:0045893],
thymus development [GO:0048538],
neuron fate commitment [GO:0048663],
embryonic cranial skeleton morphogenesis [GO:0048701],
skeletal system morphogenesis [GO:0048705],
mesenchymal cell differentiation [GO:0048762],
artery morphogenesis [GO:0048844],
cell motility [GO:0048870],
positive regulation of cellular component movement [GO:0051272],
positive regulation of filopodium assembly [GO:0051491],
positive regulation of stress fiber assembly [GO:0051496],
positive regulation of protein kinase B signaling [GO:0051897],
parathyroid gland development [GO:0060017],
palate development [GO:0060021],
pharyngeal system development [GO:0060037],
regulation of cardiac muscle cell proliferation [GO:0060043],
cardiac epithelial to mesenchymal transition [GO:0060317],
pathway-restricted SMAD protein phosphorylation [GO:0060389],
positive regulation of SMAD protein import into nucleus [GO:0060391],
ventricular septum morphogenesis [GO:0060412],
angiogenesis involved in coronary vascular morphogenesis [GO:0060978],
coronary artery morphogenesis [GO:0060982],
response to cholesterol [GO:0070723],
cellular response to growth factor stimulus [GO:0071363],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007],
positive regulation of occluding junction disassembly [GO:1905075],
epicardium morphogenesis [GO:1905223],
positive regulation of apoptotic signaling pathway [GO:2001235],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
angiogenesis [GO:0001525],
transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178],
embryo development [GO:0009790],
regulation of gene expression [GO:0010468],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],
regulation of growth [GO:0040008],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
response to estrogen [GO:0043627],
negative regulation of endothelial cell differentiation [GO:0045602],
protein autophosphorylation [GO:0046777],
negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
transforming growth factor beta-activated receptor activity [GO:0005024],
transforming growth factor beta receptor activity, type I [GO:0005025],
type II transforming growth factor beta receptor binding [GO:0005114],
protein binding [GO:0005515],
ATP binding [GO:0005524],
activin receptor activity, type I [GO:0016361],
growth factor binding [GO:0019838],
SMAD binding [GO:0046332],
metal ion binding [GO:0046872],
activin binding [GO:0048185],
transforming growth factor beta binding [GO:0050431],
I-SMAD binding [GO:0070411],
nucleotide binding [GO:0000166],
transmembrane receptor protein serine/threonine kinase activity [GO:0004675],
receptor binding [GO:0005102],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
ubiquitin protein ligase binding [GO:0031625],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
endosome [GO:0005768],
plasma membrane [GO:0005886],
bicellular tight junction [GO:0005923],
cell surface [GO:0009986],
receptor complex [GO:0043235],
membrane raft [GO:0045121],
activin receptor complex [GO:0048179],
caveola [GO:0005901],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
cell junction [GO:0030054],
macromolecular complex [GO:0032991],