TGFB3

transforming growth factor beta 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30790400 Primary endothelial cells derived from lung Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
response to hypoxia [GO:0001666],
in utero embryonic development [GO:0001701],
platelet degranulation [GO:0002576],
transforming growth factor beta receptor signaling pathway [GO:0007179],
salivary gland morphogenesis [GO:0007435],
female pregnancy [GO:0007565],
aging [GO:0007568],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
negative regulation of macrophage cytokine production [GO:0010936],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
mammary gland development [GO:0030879],
response to progesterone [GO:0032570],
positive regulation of collagen biosynthetic process [GO:0032967],
response to laminar fluid shear stress [GO:0034616],
wound healing [GO:0042060],
regulation of cell proliferation [GO:0042127],
odontogenesis [GO:0042476],
uterine wall breakdown [GO:0042704],
positive regulation of apoptotic process [GO:0043065],
negative regulation of neuron apoptotic process [GO:0043524],
response to estrogen [GO:0043627],
ossification involved in bone remodeling [GO:0043932],
cell-cell junction organization [GO:0045216],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
lung alveolus development [GO:0048286],
digestive tract development [GO:0048565],
embryonic neurocranium morphogenesis [GO:0048702],
inner ear development [GO:0048839],
positive regulation of protein secretion [GO:0050714],
positive regulation of filopodium assembly [GO:0051491],
positive regulation of stress fiber assembly [GO:0051496],
positive regulation of cell division [GO:0051781],
face morphogenesis [GO:0060325],
frontal suture morphogenesis [GO:0060364],
positive regulation of SMAD protein import into nucleus [GO:0060391],
SMAD protein signal transduction [GO:0060395],
detection of hypoxia [GO:0070483],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905005],
positive regulation of occluding junction disassembly [GO:1905075],
embryo development [GO:0009790],
animal organ morphogenesis [GO:0009887],
gene expression [GO:0010467],
positive regulation of gene expression [GO:0010628],
cell growth [GO:0016049],
palate development [GO:0060021],
cellular response to growth factor stimulus [GO:0071363],

Molecular Function:
type II transforming growth factor beta receptor binding [GO:0005114],
cytokine activity [GO:0005125],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
type I transforming growth factor beta receptor binding [GO:0034713],
type III transforming growth factor beta receptor binding [GO:0034714],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
transforming growth factor beta binding [GO:0050431],
transforming growth factor beta receptor binding [GO:0005160],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
T-tubule [GO:0030315],
platelet alpha granule lumen [GO:0031093],
neuronal cell body [GO:0043025],
intracellular membrane-bounded organelle [GO:0043231],
cytoplasm [GO:0005737],
secretory granule [GO:0030141],
extracellular matrix [GO:0031012],