TGFB1

transforming growth factor beta 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
vasculogenesis [GO:0001570],
epithelial to mesenchymal transition [GO:0001837],
neural tube closure [GO:0001843],
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of protein phosphorylation [GO:0001934],
chondrocyte differentiation [GO:0002062],
hematopoietic progenitor cell differentiation [GO:0002244],
connective tissue replacement involved in inflammatory response wound healing [GO:0002248],
platelet degranulation [GO:0002576],
heart valve morphogenesis [GO:0003179],
aortic valve morphogenesis [GO:0003180],
protein phosphorylation [GO:0006468],
protein export from nucleus [GO:0006611],
ATP biosynthetic process [GO:0006754],
phosphate-containing compound metabolic process [GO:0006796],
inflammatory response [GO:0006954],
cell cycle arrest [GO:0007050],
mitotic cell cycle checkpoint [GO:0007093],
epidermal growth factor receptor signaling pathway [GO:0007173],
transforming growth factor beta receptor signaling pathway [GO:0007179],
common-partner SMAD protein phosphorylation [GO:0007182],
SMAD protein complex assembly [GO:0007183],
salivary gland morphogenesis [GO:0007435],
heart development [GO:0007507],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
response to wounding [GO:0009611],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of extracellular matrix disassembly [GO:0010716],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
macrophage derived foam cell differentiation [GO:0010742],
positive regulation of fibroblast migration [GO:0010763],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
negative regulation of macrophage cytokine production [GO:0010936],
positive regulation of microglia differentiation [GO:0014008],
regulation of striated muscle tissue development [GO:0016202],
cell migration [GO:0016477],
regulation of transforming growth factor beta receptor signaling pathway [GO:0017015],
cytokine-mediated signaling pathway [GO:0019221],
neural tube development [GO:0021915],
negative regulation of cell-cell adhesion [GO:0022408],
hyaluronan catabolic process [GO:0030214],
negative regulation of cell growth [GO:0030308],
regulation of cell migration [GO:0030334],
positive regulation of cell migration [GO:0030335],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
membrane protein intracellular domain proteolysis [GO:0031293],
positive regulation of protein complex assembly [GO:0031334],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
positive regulation of cellular protein metabolic process [GO:0032270],
response to estradiol [GO:0032355],
response to progesterone [GO:0032570],
positive regulation of interleukin-17 production [GO:0032740],
receptor catabolic process [GO:0032801],
positive regulation of superoxide anion generation [GO:0032930],
positive regulation of collagen biosynthetic process [GO:0032967],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
positive regulation of protein dephosphorylation [GO:0035307],
regulation of cell proliferation [GO:0042127],
regulation of protein import into nucleus [GO:0042306],
positive regulation of protein import into nucleus [GO:0042307],
positive regulation of vascular permeability [GO:0043117],
positive regulation of MAP kinase activity [GO:0043406],
protein kinase B signaling [GO:0043491],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
ossification involved in bone remodeling [GO:0043932],
cell-cell junction organization [GO:0045216],
negative regulation of cell differentiation [GO:0045596],
negative regulation of fat cell differentiation [GO:0045599],
negative regulation of myoblast differentiation [GO:0045662],
negative regulation of cell cycle [GO:0045786],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of cytolysis [GO:0045918],
negative regulation of mitotic cell cycle [GO:0045930],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of isotype switching to IgA isotypes [GO:0048298],
lymph node development [GO:0048535],
negative regulation of skeletal muscle tissue development [GO:0048642],
negative regulation of epithelial cell proliferation [GO:0050680],
positive regulation of protein secretion [GO:0050714],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
leukocyte migration [GO:0050900],
positive regulation of chemotaxis [GO:0050921],
regulation of binding [GO:0051098],
regulation of DNA binding [GO:0051101],
positive regulation of cell division [GO:0051781],
positive regulation of protein kinase B signaling [GO:0051897],
ventricular cardiac muscle tissue morphogenesis [GO:0055010],
regulation of blood vessel remodeling [GO:0060312],
pathway-restricted SMAD protein phosphorylation [GO:0060389],
regulation of SMAD protein import into nucleus [GO:0060390],
positive regulation of SMAD protein import into nucleus [GO:0060391],
SMAD protein signal transduction [GO:0060395],
negative regulation of gene silencing by miRNA [GO:0060965],
negative regulation of biomineral tissue development [GO:0070168],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
response to cholesterol [GO:0070723],
cellular response to organic cyclic compound [GO:0071407],
cellular response to transforming growth factor beta stimulus [GO:0071560],
extracellular matrix assembly [GO:0085029],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
extrinsic apoptotic signaling pathway [GO:0097191],
negative regulation of hyaluronan biosynthetic process [GO:1900126],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of extracellular matrix assembly [GO:1901203],
positive regulation of NAD+ ADP-ribosyltransferase activity [GO:1901666],
regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902893],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
negative regulation of protein localization to plasma membrane [GO:1903077],
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905005],
transforming growth factor beta receptor signaling pathway involved in heart development [GO:1905313],
embryonic liver development [GO:1990402],
positive regulation of transcription regulatory region DNA binding [GO:2000679],
positive regulation of cardiac muscle cell differentiation [GO:2000727],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
skeletal system development [GO:0001501],
ureteric bud development [GO:0001657],
morphogenesis of a branching structure [GO:0001763],
cell activation [GO:0001775],
regulation of sodium ion transport [GO:0002028],
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362],
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [GO:0002460],
tolerance induction to self antigen [GO:0002513],
cellular calcium ion homeostasis [GO:0006874],
defense response [GO:0006952],
Notch signaling pathway [GO:0007219],
negative regulation of neuroblast proliferation [GO:0007406],
endoderm development [GO:0007492],
skeletal muscle tissue development [GO:0007519],
cell proliferation [GO:0008283],
germ cell migration [GO:0008354],
defense response to fungus, incompatible interaction [GO:0009817],
animal organ morphogenesis [GO:0009887],
response to organic substance [GO:0010033],
regulation of gene expression [GO:0010468],
oligodendrocyte development [GO:0014003],
cell growth [GO:0016049],
T cell differentiation [GO:0030217],
negative regulation of ossification [GO:0030279],
osteoclast differentiation [GO:0030316],
mammary gland development [GO:0030879],
positive regulation of histone deacetylation [GO:0031065],
animal organ regeneration [GO:0031100],
positive regulation of exit from mitosis [GO:0031536],
regulation of interleukin-23 production [GO:0032667],
negative regulation of interleukin-17 production [GO:0032700],
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032829],
mononuclear cell proliferation [GO:0032943],
positive regulation of histone acetylation [GO:0035066],
wound healing [GO:0042060],
T cell activation [GO:0042110],
negative regulation of T cell proliferation [GO:0042130],
positive regulation of odontogenesis [GO:0042482],
myelination [GO:0042552],
myeloid dendritic cell differentiation [GO:0043011],
T cell homeostasis [GO:0043029],
positive regulation of apoptotic process [GO:0043065],
regulatory T cell differentiation [GO:0045066],
regulation of regulatory T cell differentiation [GO:0045589],
positive regulation of regulatory T cell differentiation [GO:0045591],
muscle cell cellular homeostasis [GO:0046716],
positive regulation of fibroblast proliferation [GO:0048146],
positive regulation of epithelial cell proliferation [GO:0050679],
negative regulation of phagocytosis [GO:0050765],
negative regulation of immune response [GO:0050777],
negative regulation of T cell activation [GO:0050868],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of smooth muscle cell differentiation [GO:0051152],
negative regulation of release of sequestered calcium ion into cytosol [GO:0051280],
face morphogenesis [GO:0060325],
mammary gland branching involved in thelarche [GO:0060744],
branch elongation involved in mammary gland duct branching [GO:0060751],
regulation of branching involved in mammary gland duct morphogenesis [GO:0060762],
regulation of cartilage development [GO:0061035],
connective tissue development [GO:0061448],
lens fiber cell differentiation [GO:0070306],
positive regulation of cell cycle arrest [GO:0071158],
cellular response to growth factor stimulus [GO:0071363],
cellular response to dexamethasone stimulus [GO:0071549],
positive regulation of mononuclear cell migration [GO:0071677],
T-helper 17 cell lineage commitment [GO:0072540],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
positive regulation of receptor clustering [GO:1903911],
regulation of actin cytoskeleton reorganization [GO:2000249],

Molecular Function:
antigen binding [GO:0003823],
type II transforming growth factor beta receptor binding [GO:0005114],
cytokine activity [GO:0005125],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
enzyme binding [GO:0019899],
type I transforming growth factor beta receptor binding [GO:0034713],
type III transforming growth factor beta receptor binding [GO:0034714],
identical protein binding [GO:0042802],
transforming growth factor beta receptor binding [GO:0005160],
protein serine/threonine kinase activator activity [GO:0043539],
macromolecular complex binding [GO:0044877],
protein N-terminus binding [GO:0047485],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
Golgi lumen [GO:0005796],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
cell surface [GO:0009986],
extracellular matrix [GO:0031012],
platelet alpha granule lumen [GO:0031093],
blood microparticle [GO:0072562],
secretory granule [GO:0030141],
axon [GO:0030424],
neuronal cell body [GO:0043025],