TGFA

transforming growth factor alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPK activity [GO:0000187],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
ER to Golgi vesicle-mediated transport [GO:0006888],
signal transduction [GO:0007165],
epidermal growth factor receptor signaling pathway [GO:0007173],
positive regulation of cell proliferation [GO:0008284],
intracellular signal transduction [GO:0035556],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
positive regulation of epidermal growth factor-activated receptor activity [GO:0045741],
positive regulation of mitotic nuclear division [GO:0045840],
COPII vesicle coating [GO:0048208],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of cell division [GO:0051781],
positive regulation of protein kinase B signaling [GO:0051897],
membrane organization [GO:0061024],
angiogenesis [GO:0001525],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cellular process [GO:0048523],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
mammary gland alveolus development [GO:0060749],
hepatocyte proliferation [GO:0072574],

Molecular Function:
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
growth factor activity [GO:0008083],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
ER to Golgi transport vesicle membrane [GO:0012507],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
clathrin-coated vesicle membrane [GO:0030665],
cytoplasmic vesicle [GO:0031410],
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116],
perinuclear region of cytoplasm [GO:0048471],
nucleus [GO:0005634],
membrane [GO:0016020],