TFRC

transferrin receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of cell growth [GO:0001558],
positive regulation of protein phosphorylation [GO:0001934],
iron ion transport [GO:0006826],
cellular iron ion homeostasis [GO:0006879],
positive regulation of gene expression [GO:0010628],
negative regulation of mitochondrial fusion [GO:0010637],
osteoclast differentiation [GO:0030316],
positive regulation of B cell proliferation [GO:0030890],
positive regulation of protein complex assembly [GO:0031334],
receptor internalization [GO:0031623],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
transferrin transport [GO:0033572],
intracellular signal transduction [GO:0035556],
cellular response to drug [GO:0035690],
positive regulation of T cell proliferation [GO:0042102],
regulation of cell proliferation [GO:0042127],
negative regulation of apoptotic process [GO:0043066],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of bone resorption [GO:0045780],
positive regulation of isotype switching [GO:0045830],
viral entry into host cell [GO:0046718],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
membrane organization [GO:0061024],
positive regulation of protein localization to nucleus [GO:1900182],
cellular response to leukemia inhibitory factor [GO:1990830],
endocytosis [GO:0006897],
receptor-mediated endocytosis [GO:0006898],
cellular response to extracellular stimulus [GO:0031668],
cellular response to iron ion [GO:0071281],

Molecular Function:
virus receptor activity [GO:0001618],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
transferrin receptor activity [GO:0004998],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
macromolecular complex binding [GO:0044877],
iron ion transmembrane transporter activity [GO:0005381],
Hsp70 protein binding [GO:0030544],
chaperone binding [GO:0051087],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endosome [GO:0005768],
early endosome [GO:0005769],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
clathrin-coated pit [GO:0005905],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
endosome membrane [GO:0010008],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
clathrin-coated vesicle membrane [GO:0030665],
cytoplasmic vesicle [GO:0031410],
melanosome [GO:0042470],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],
recycling endosome [GO:0055037],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
extracellular vesicle [GO:1903561],
HFE-transferrin receptor complex [GO:1990712],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
integral component of membrane [GO:0016021],
recycling endosome membrane [GO:0055038],