TFR2

transferrin receptor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
iron ion transport [GO:0006826],
cellular iron ion homeostasis [GO:0006879],
receptor-mediated endocytosis [GO:0006898],
acute-phase response [GO:0006953],
response to iron ion [GO:0010039],
transferrin transport [GO:0033572],
positive regulation of endocytosis [GO:0045807],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
iron ion homeostasis [GO:0055072],
cellular response to iron ion [GO:0071281],
positive regulation of peptide hormone secretion [GO:0090277],
positive regulation of protein maturation [GO:1903319],

Molecular Function:
transferrin receptor activity [GO:0004998],
protein binding [GO:0005515],
co-receptor binding [GO:0039706],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
cytoplasmic vesicle [GO:0031410],
HFE-transferrin receptor complex [GO:1990712],
cytoplasm [GO:0005737],
membrane [GO:0016020],
integral component of membrane [GO:0016021],