TFAP2A

transcription factor AP-2 alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES
31811565 Primary neurons cells derived from brain Brain Human, mouse, rat YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32100207 HFL-1 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
kidney development [GO:0001822],
optic vesicle morphogenesis [GO:0003404],
optic cup structural organization [GO:0003409],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
sensory perception of sound [GO:0007605],
negative regulation of cell proliferation [GO:0008285],
positive regulation of gene expression [GO:0010628],
retina layer formation [GO:0010842],
negative regulation of transcription by competitive promoter binding [GO:0010944],
trigeminal nerve development [GO:0021559],
oculomotor nerve formation [GO:0021623],
positive regulation of bone mineralization [GO:0030501],
embryonic forelimb morphogenesis [GO:0035115],
regulation of cell proliferation [GO:0042127],
inner ear morphogenesis [GO:0042472],
negative regulation of apoptotic process [GO:0043066],
positive regulation of neuron apoptotic process [GO:0043525],
regulation of cell differentiation [GO:0045595],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
embryonic cranial skeleton morphogenesis [GO:0048701],
anatomical structure development [GO:0048856],
palate development [GO:0060021],
bone morphogenesis [GO:0060349],
eyelid development in camera-type eye [GO:0061029],
positive regulation of tooth mineralization [GO:0070172],
cellular response to iron ion [GO:0071281],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
neural tube closure [GO:0001843],
lens morphogenesis in camera-type eye [GO:0002089],
outflow tract morphogenesis [GO:0003151],
keratinocyte development [GO:0003334],
regulation of transcription, DNA-templated [GO:0006355],
nervous system development [GO:0007399],
sensory organ development [GO:0007423],
embryonic pattern specification [GO:0009880],
embryonic body morphogenesis [GO:0010172],
neural crest cell development [GO:0014032],
anterior neuropore closure [GO:0021506],
forebrain neuron development [GO:0021884],
positive regulation of cell migration [GO:0030335],
response to lipopolysaccharide [GO:0032496],
forelimb morphogenesis [GO:0035136],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
negative regulation of neuron apoptotic process [GO:0043524],
skin development [GO:0043588],
regulation of neuron differentiation [GO:0045664],
sympathetic nervous system development [GO:0048485],
embryonic camera-type eye morphogenesis [GO:0048596],
skeletal system morphogenesis [GO:0048705],
epidermis morphogenesis [GO:0048730],
lens induction in camera-type eye [GO:0060235],
face morphogenesis [GO:0060325],
cornea development in camera-type eye [GO:0061303],
basement membrane organization [GO:0071711],
metanephric nephron development [GO:0072210],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription corepressor activity [GO:0003714],
transcription factor binding [GO:0008134],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytosol [GO:0005829],
clathrin-coated pit [GO:0005905],