BRAF

B-Raf proto-oncogene, serine/threonine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16079850 BJ, Phoenix-AMPHO Skin Human NO
17299132 Lung Mouse NO
17696195 Skin Human NO
18267069 BJ, primary melanocytes derived from skin Human NO
18650848 SK-MEL-28, Mel2a, FM88, NIH 3T3 Human NO
19345328 Skin Mouse NO
19389934 Primary melanocytes derived from skin Skin Human, mouse NO
20027224 COLO 32DM Human NO
20478260 Skin Human NO
20941790 Intestine Mouse NO
20959475 HEK 293T Human NO
21636552 Primary neurosphere cells derived from brain Human NO
22549727 TIG-3, HCA2, HEK 293T Human NO
24703243 TIG-3 Skin Human NO
24934810 Lung Mouse NO
25188864 Ovary Human NO
25499223 Primary cells derived from thymus Human, mouse NO
25673642 Skin Mouse NO
26028035 Lung Mouse NO
28745322 Lung Mouse NO
31172672 Primary melanocytes derived from skin Human NO
31433975 IMR-90 Human NO
31945054 IMR-90 Human YES
32058953 IMR90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23603840 SK-MEL-28, FM55M2 Human NO
29507566 Primary melanocytes derived from skin Human NO
29548335 Li Fraumeni Human YES
30159130 MM34, MM43, MM5, MM74, SK-MEL-28 Human, mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
protein phosphorylation [GO:0006468],
epidermal growth factor receptor signaling pathway [GO:0007173],
animal organ morphogenesis [GO:0009887],
positive regulation of gene expression [GO:0010628],
positive regulation of glucose transport [GO:0010828],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of apoptotic process [GO:0043066],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
trehalose metabolism in response to stress [GO:0070413],
cellular response to calcium ion [GO:0071277],
establishment of protein localization to membrane [GO:0090150],
myeloid progenitor cell differentiation [GO:0002318],
signal transduction [GO:0007165],
metabolic process [GO:0008152],
visual learning [GO:0008542],
negative regulation of fibroblast migration [GO:0010764],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],
thyroid gland development [GO:0030878],
somatic stem cell population maintenance [GO:0035019],
intracellular signal transduction [GO:0035556],
cellular response to drug [GO:0035690],
regulation of cell proliferation [GO:0042127],
CD4-positive, alpha-beta T cell differentiation [GO:0043367],
positive T cell selection [GO:0043368],
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369],
response to peptide hormone [GO:0043434],
negative regulation of neuron apoptotic process [GO:0043524],
regulation of T cell differentiation [GO:0045580],
alpha-beta T cell differentiation [GO:0046632],
thymus development [GO:0048538],
regulation of axon regeneration [GO:0048679],
positive regulation of axon regeneration [GO:0048680],
positive regulation of axonogenesis [GO:0050772],
T cell receptor signaling pathway [GO:0050852],
positive regulation of stress fiber assembly [GO:0051496],
response to cAMP [GO:0051591],
long-term synaptic potentiation [GO:0060291],
head morphogenesis [GO:0060323],
face development [GO:0060324],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
negative regulation of synaptic vesicle exocytosis [GO:2000301],
negative regulation of endothelial cell apoptotic process [GO:2000352],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
ATP binding [GO:0005524],
small GTPase binding [GO:0031267],
identical protein binding [GO:0042802],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
MAP kinase kinase kinase activity [GO:0004709],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Ras GTPase binding [GO:0017016],
mitogen-activated protein kinase kinase binding [GO:0031434],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
intracellular membrane-bounded organelle [GO:0043231],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
membrane [GO:0016020],
neuron projection [GO:0043005],
cell body [GO:0044297],