TEK

TEK receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
angiogenesis [GO:0001525],
response to hypoxia [GO:0001666],
positive regulation of protein phosphorylation [GO:0001934],
endothelial cell proliferation [GO:0001935],
positive regulation of endothelial cell proliferation [GO:0001938],
endochondral ossification [GO:0001958],
sprouting angiogenesis [GO:0002040],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
cell-cell signaling [GO:0007267],
multicellular organism development [GO:0007275],
heart development [GO:0007507],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
negative regulation of angiogenesis [GO:0016525],
peptidyl-tyrosine phosphorylation [GO:0018108],
regulation of establishment or maintenance of cell polarity [GO:0032878],
positive regulation of kinase activity [GO:0033674],
substrate adhesion-dependent cell spreading [GO:0034446],
negative regulation of apoptotic process [GO:0043066],
regulation of vascular permeability [GO:0043114],
positive regulation of MAPK cascade [GO:0043410],
response to peptide hormone [GO:0043434],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
response to estrogen [GO:0043627],
positive regulation of angiogenesis [GO:0045766],
protein autophosphorylation [GO:0046777],
Tie signaling pathway [GO:0048014],
negative regulation of inflammatory response [GO:0050728],
leukocyte migration [GO:0050900],
response to cAMP [GO:0051591],
positive regulation of focal adhesion assembly [GO:0051894],
positive regulation of protein kinase B signaling [GO:0051897],
definitive hemopoiesis [GO:0060216],
heart trabecula formation [GO:0060347],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
glomerulus vasculature development [GO:0072012],
positive regulation of intracellular signal transduction [GO:1902533],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
regulation of endothelial cell apoptotic process [GO:2000351],
negative regulation of endothelial cell apoptotic process [GO:2000352],
patterning of blood vessels [GO:0001569],
vasculogenesis [GO:0001570],
regulation of endothelial cell proliferation [GO:0001936],
positive regulation of cytokine production involved in immune response [GO:0002720],
protein phosphorylation [GO:0006468],
cell-matrix adhesion [GO:0007160],
phosphorylation [GO:0016310],
hemopoiesis [GO:0030097],
regulation of cell migration [GO:0030334],
positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949],
response to retinoic acid [GO:0032526],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
positive regulation of protein import into nucleus [GO:0042307],
regulation of angiogenesis [GO:0045765],
positive regulation of cell adhesion [GO:0045785],
cell-cell adhesion [GO:0098609],
regulation of NIK/NF-kappaB signaling [GO:1901222],

Molecular Function:
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
protein binding [GO:0005515],
ATP binding [GO:0005524],
growth factor binding [GO:0019838],
signaling receptor activity [GO:0038023],
identical protein binding [GO:0042802],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
stress fiber [GO:0001725],
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
microvillus [GO:0005902],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
basal plasma membrane [GO:0009925],
cell surface [GO:0009986],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
centriolar satellite [GO:0034451],
receptor complex [GO:0043235],
membrane raft [GO:0045121],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
perinuclear region of cytoplasm [GO:0048471],