TEA domain transcription factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
vasculogenesis [GO:0001570],
neural tube closure [GO:0001843],
embryonic heart tube morphogenesis [GO:0003143],
regulation of transcription, DNA-templated [GO:0006355],
transcription initiation from RNA polymerase II promoter [GO:0006367],
notochord development [GO:0030903],
hippo signaling [GO:0035329],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
paraxial mesoderm development [GO:0048339],
lateral mesoderm development [GO:0048368],
embryonic organ development [GO:0048568],
negative regulation of cell death [GO:0060548],
macromolecular complex assembly [GO:0065003],
cellular response to retinoic acid [GO:0071300],
regulation of stem cell differentiation [GO:2000736],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcription coactivator binding [GO:0001223],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
disordered domain specific binding [GO:0097718],
DNA binding [GO:0003677],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytosol [GO:0005829],
intracellular membrane-bounded organelle [GO:0043231],
TEAD-2-YAP complex [GO:0071149],