TDG

thymine DNA glycosylase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30674989 SK28, 888-Mel, Mull, Rosi, MEL51, MNT-1, HEMn-LP Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
base-excision repair [GO:0006284],
base-excision repair, AP site formation [GO:0006285],
mismatch repair [GO:0006298],
chromatin organization [GO:0006325],
negative regulation of protein binding [GO:0032091],
oxidative DNA demethylation [GO:0035511],
negative regulation of chromatin binding [GO:0035562],
regulation of gene expression, epigenetic [GO:0040029],
depyrimidination [GO:0045008],
regulation of embryonic development [GO:0045995],
DNA demethylation [GO:0080111],
regulation of DNA N-glycosylase activity [GO:1902544],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
magnesium ion binding [GO:0000287],
DNA binding [GO:0003677],
damaged DNA binding [GO:0003684],
double-stranded DNA binding [GO:0003690],
transcription cofactor activity [GO:0003712],
uracil DNA N-glycosylase activity [GO:0004844],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
ATP binding [GO:0005524],
transcription factor binding [GO:0008134],
pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263],
DNA N-glycosylase activity [GO:0019104],
protein domain specific binding [GO:0019904],
mismatched DNA binding [GO:0030983],
sodium ion binding [GO:0031402],
chloride ion binding [GO:0031404],
SUMO binding [GO:0032183],
protein homodimerization activity [GO:0042803],
protein self-association [GO:0043621],
G/U mismatch-specific uracil-DNA glycosylase activity [GO:0043739],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
plasma membrane [GO:0005886],
PML body [GO:0016605],