TCIRG1

T cell immune regulator 1, ATPase H+ transporting V0 subunit a3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
ossification [GO:0001503],
osteoclast proliferation [GO:0002158],
immunoglobulin production [GO:0002377],
cellular calcium ion homeostasis [GO:0006874],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
cellular defense response [GO:0006968],
vacuolar acidification [GO:0007035],
protein catabolic process in the vacuole [GO:0007039],
positive regulation of cell proliferation [GO:0008284],
insulin receptor signaling pathway [GO:0008286],
regulation of proton transport [GO:0010155],
response to silver ion [GO:0010272],
regulation of gene expression [GO:0010468],
immunoglobulin mediated immune response [GO:0016064],
macroautophagy [GO:0016236],
optic nerve development [GO:0021554],
establishment of cell polarity [GO:0030010],
B cell differentiation [GO:0030183],
T cell differentiation [GO:0030217],
osteoclast differentiation [GO:0030316],
ruffle organization [GO:0031529],
protein localization to organelle [GO:0033365],
transferrin transport [GO:0033572],
ion transmembrane transport [GO:0034220],
memory T cell activation [GO:0035709],
T-helper 1 cell activation [GO:0035711],
T cell homeostasis [GO:0043029],
neutrophil degranulation [GO:0043312],
tooth eruption [GO:0044691],
bone resorption [GO:0045453],
regulation of osteoblast differentiation [GO:0045667],
regulation of insulin secretion [GO:0050796],
establishment of vesicle localization [GO:0051650],
retina development in camera-type eye [GO:0060041],
hematopoietic stem cell homeostasis [GO:0061484],
enamel mineralization [GO:0070166],
cellular response to cytokine stimulus [GO:0071345],
interferon-gamma secretion [GO:0072643],
phagosome acidification [GO:0090383],
dentin mineralization [GO:0097188],
hydrogen ion transmembrane transport [GO:1902600],
autophagy [GO:0006914],
gene expression [GO:0010467],
myeloid cell differentiation [GO:0030099],
odontogenesis [GO:0042476],
pH reduction [GO:0045851],
homeostasis of number of cells [GO:0048872],
intracellular pH reduction [GO:0051452],

Molecular Function:
transporter activity [GO:0005215],
proton-transporting ATPase activity, rotational mechanism [GO:0046961],
ATPase binding [GO:0051117],
protein binding [GO:0005515],

Cellular Component:
vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220],
nucleus [GO:0005634],
lysosomal membrane [GO:0005765],
late endosome [GO:0005770],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
endosome membrane [GO:0010008],
apical plasma membrane [GO:0016324],
vacuolar proton-transporting V-type ATPase complex [GO:0016471],
phagocytic vesicle membrane [GO:0030670],
ficolin-1-rich granule membrane [GO:0101003],
mitochondrion [GO:0005739],
lysosome [GO:0005764],
secretory granule membrane [GO:0030667],
phagocytic vesicle [GO:0045335],