TCF7L2

transcription factor 7 like 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
blood vessel development [GO:0001568],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
cell cycle arrest [GO:0007050],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
response to glucose [GO:0009749],
positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909],
Wnt signaling pathway [GO:0016055],
pancreas development [GO:0031016],
positive regulation of insulin secretion [GO:0032024],
positive regulation of protein binding [GO:0032092],
regulation of hormone metabolic process [GO:0032350],
glucose homeostasis [GO:0042593],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
maintenance of DNA repeat elements [GO:0043570],
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [GO:0044334],
fat cell differentiation [GO:0045444],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of protein export from nucleus [GO:0046827],
myoblast fate commitment [GO:0048625],
regulation of smooth muscle cell proliferation [GO:0048660],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of protein kinase B signaling [GO:0051897],
canonical Wnt signaling pathway [GO:0060070],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
beta-catenin-TCF complex assembly [GO:1904837],
negative regulation of type B pancreatic cell apoptotic process [GO:2000675],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
cellular glucose homeostasis [GO:0001678],
in utero embryonic development [GO:0001701],
glycogen metabolic process [GO:0005977],
glucose metabolic process [GO:0006006],
regulation of gluconeogenesis [GO:0006111],
regulation of transcription, DNA-templated [GO:0006355],
cellular response to starvation [GO:0009267],
post-embryonic development [GO:0009791],
positive regulation of triglyceride biosynthetic process [GO:0010867],
oligodendrocyte development [GO:0014003],
neural tube development [GO:0021915],
pituitary gland development [GO:0021983],
bone mineralization [GO:0030282],
negative regulation of BMP signaling pathway [GO:0030514],
embryonic genitalia morphogenesis [GO:0030538],
regulation of myelination [GO:0031641],
secretory granule localization [GO:0032252],
somatic stem cell population maintenance [GO:0035019],
multicellular organism growth [GO:0035264],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
odontogenesis of dentin-containing tooth [GO:0042475],
positive regulation of apoptotic process [GO:0043065],
skin development [GO:0043588],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of gluconeogenesis [GO:0045722],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of organ growth [GO:0046621],
positive regulation of lipid biosynthetic process [GO:0046889],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic hindgut morphogenesis [GO:0048619],
regulation of skeletal muscle tissue development [GO:0048641],
regulation of oligodendrocyte differentiation [GO:0048713],
face morphogenesis [GO:0060325],
regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178],
insulin metabolic process [GO:1901142],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II repressing transcription factor binding [GO:0001103],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
transcription factor binding [GO:0008134],
protein kinase binding [GO:0019901],
nuclear hormone receptor binding [GO:0035257],
sequence-specific DNA binding [GO:0043565],
gamma-catenin binding [GO:0045295],
armadillo repeat domain binding [GO:0070016],
DNA binding [GO:0003677],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
PML body [GO:0016605],
protein-DNA complex [GO:0032993],
beta-catenin-TCF7L2 complex [GO:0070369],
cytosol [GO:0005829],
catenin-TCF7L2 complex [GO:0071664],