TAB1

TGF-beta activated kinase 1 (MAP3K7) binding protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA774 Skin, Lung Human YES

GO terms:

Biological Process:
activation of MAPKKK activity [GO:0000185],
activation of MAPK activity [GO:0000187],
in utero embryonic development [GO:0001701],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
heart morphogenesis [GO:0003007],
cardiac septum development [GO:0003279],
negative regulation of protein kinase activity [GO:0006469],
protein dephosphorylation [GO:0006470],
transforming growth factor beta receptor signaling pathway [GO:0007179],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
JNK cascade [GO:0007254],
protein deubiquitination [GO:0016579],
lung development [GO:0030324],
aorta development [GO:0035904],
Fc-epsilon receptor signaling pathway [GO:0038095],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
coronary vasculature development [GO:0060976],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
positive regulation of MAP kinase activity [GO:0043406],

Molecular Function:
protein serine/threonine phosphatase activity [GO:0004722],
magnesium-dependent protein serine/threonine phosphatase activity [GO:0004724],
protein binding [GO:0005515],
enzyme activator activity [GO:0008047],
kinase activator activity [GO:0019209],
macromolecular complex binding [GO:0044877],
catalytic activity [GO:0003824],
mitogen-activated protein kinase p38 binding [GO:0048273],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
endosome membrane [GO:0010008],
nuclear speck [GO:0016607],
macromolecular complex [GO:0032991],