SULF2

sulfatase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27545311 U2OS Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
kidney development [GO:0001822],
chondrocyte development [GO:0002063],
glomerular filtration [GO:0003094],
response to wounding [GO:0009611],
positive regulation of vascular endothelial growth factor production [GO:0010575],
esophagus smooth muscle contraction [GO:0014846],
positive regulation of Wnt signaling pathway [GO:0030177],
heparan sulfate proteoglycan metabolic process [GO:0030201],
glomerular basement membrane development [GO:0032836],
glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
embryonic skeletal system development [GO:0048706],
cartilage development [GO:0051216],
bone development [GO:0060348],
innervation [GO:0060384],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
liver regeneration [GO:0097421],
regulation of hepatocyte proliferation [GO:2000345],
sulfur compound metabolic process [GO:0006790],

Molecular Function:
arylsulfatase activity [GO:0004065],
calcium ion binding [GO:0005509],
glycosaminoglycan binding [GO:0005539],
N-acetylglucosamine-6-sulfatase activity [GO:0008449],
catalytic activity [GO:0003824],
sulfuric ester hydrolase activity [GO:0008484],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
endoplasmic reticulum [GO:0005783],
Golgi stack [GO:0005795],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
Golgi apparatus [GO:0005794],