ACOT2

acyl-CoA thioesterase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA745 Skin, Lung Human YES

GO terms:

Biological Process:
very long-chain fatty acid metabolic process [GO:0000038],
long-chain fatty acid metabolic process [GO:0001676],
protein targeting to peroxisome [GO:0006625],
fatty acid metabolic process [GO:0006631],
acyl-CoA metabolic process [GO:0006637],
response to hypoxia [GO:0001666],
lipid metabolic process [GO:0006629],
very long-chain fatty acid catabolic process [GO:0042760],

Molecular Function:
protein binding [GO:0005515],
palmitoyl-CoA hydrolase activity [GO:0016290],
acyl-CoA hydrolase activity [GO:0047617],
carboxylic ester hydrolase activity [GO:0052689],
hydrolase activity [GO:0016787],
thiolester hydrolase activity [GO:0016790],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
peroxisomal matrix [GO:0005782],
cytosol [GO:0005829],