STING1

stimulator of interferon response cGAMP interactor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31183403 IMR-90 Human YES
32047109 NIH/3T3 Mouse NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
activation of innate immune response [GO:0002218],
positive regulation of defense response to virus by host [GO:0002230],
immune system process [GO:0002376],
autophagy [GO:0006914],
regulation of gene expression [GO:0010468],
positive regulation of macroautophagy [GO:0016239],
regulation of cellular metabolic process [GO:0031323],
positive regulation of protein binding [GO:0032092],
positive regulation of type I interferon production [GO:0032481],
interferon-beta production [GO:0032608],
cellular response to interferon-beta [GO:0035458],
innate immune response [GO:0045087],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of inflammatory response [GO:0050727],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
protein oligomerization [GO:0051259],
defense response to virus [GO:0051607],
reticulophagy [GO:0061709],
cellular response to exogenous dsRNA [GO:0071360],
cellular response to organic cyclic compound [GO:0071407],
viral process [GO:0016032],
regulation of type I interferon production [GO:0032479],
neutrophil degranulation [GO:0043312],

Molecular Function:
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
cyclic-di-GMP binding [GO:0035438],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
cyclic-GMP-AMP binding [GO:0061507],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
endosome [GO:0005768],
autophagosome [GO:0005776],
peroxisome [GO:0005777],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
integral component of endoplasmic reticulum membrane [GO:0030176],
cytoplasmic vesicle [GO:0031410],
perinuclear region of cytoplasm [GO:0048471],
integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane [GO:1990701],
autophagosome membrane [GO:0000421],
cytoplasmic vesicle membrane [GO:0030659],
secretory granule membrane [GO:0030667],