STEAP3

STEAP3 metalloreductase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
apoptotic process [GO:0006915],
cell cycle [GO:0007049],
protein secretion [GO:0009306],
copper ion import [GO:0015677],
transferrin transport [GO:0033572],
regulation of apoptotic process [GO:0042981],
iron ion homeostasis [GO:0055072],
oxidation-reduction process [GO:0055114],
ferric iron import across plasma membrane [GO:0098706],
ion transport [GO:0006811],
iron ion transport [GO:0006826],
positive regulation of apoptotic process [GO:0043065],
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902167],
exosomal secretion [GO:1990182],

Molecular Function:
protein binding [GO:0005515],
cupric reductase activity [GO:0008823],
metal ion binding [GO:0046872],
ferric-chelate reductase (NADPH) activity [GO:0052851],
ferric-chelate reductase activity [GO:0000293],
oxidoreductase activity [GO:0016491],
identical protein binding [GO:0042802],

Cellular Component:
cytoplasm [GO:0005737],
endosome [GO:0005768],
multivesicular body [GO:0005771],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
integral component of membrane [GO:0016021],
membrane [GO:0016020],