SRPK2

SRSF protein kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
spliceosomal complex assembly [GO:0000245],
angiogenesis [GO:0001525],
protein phosphorylation [GO:0006468],
positive regulation of cell proliferation [GO:0008284],
RNA splicing [GO:0008380],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
peptidyl-serine phosphorylation [GO:0018105],
cell differentiation [GO:0030154],
nuclear speck organization [GO:0035063],
intracellular signal transduction [GO:0035556],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of viral genome replication [GO:0045070],
negative regulation of viral genome replication [GO:0045071],
innate immune response [GO:0045087],
positive regulation of cell cycle [GO:0045787],
regulation of mRNA splicing, via spliceosome [GO:0048024],
regulation of mRNA processing [GO:0050684],
mRNA processing [GO:0006397],
phosphorylation [GO:0016310],

Molecular Function:
magnesium ion binding [GO:0000287],
RNA binding [GO:0003723],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase activity [GO:0004707],
protein binding [GO:0005515],
ATP binding [GO:0005524],
14-3-3 protein binding [GO:0071889],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
chromatin [GO:0000785],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear speck [GO:0016607],