SRF

serum response factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30967634 HUVEC Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
15282327 Hs68 Human NO
20096952 SMCs Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
patterning of blood vessels [GO:0001569],
response to hypoxia [GO:0001666],
mesoderm formation [GO:0001707],
neuron migration [GO:0001764],
trophectodermal cell differentiation [GO:0001829],
heart looping [GO:0001947],
morphogenesis of an epithelial sheet [GO:0002011],
cell migration involved in sprouting angiogenesis [GO:0002042],
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003257],
cell-matrix adhesion [GO:0007160],
heart development [GO:0007507],
long-term memory [GO:0007616],
negative regulation of cell proliferation [GO:0008285],
associative learning [GO:0008306],
response to toxic substance [GO:0009636],
response to hormone [GO:0009725],
epithelial structure maintenance [GO:0010669],
positive regulation of transcription via serum response element binding [GO:0010735],
hippocampus development [GO:0021766],
tangential migration from the subventricular zone to the olfactory bulb [GO:0022028],
actin cytoskeleton organization [GO:0030036],
regulation of cell adhesion [GO:0030155],
platelet activation [GO:0030168],
platelet formation [GO:0030220],
negative regulation of cell migration [GO:0030336],
thyroid gland development [GO:0030878],
neuron projection development [GO:0031175],
regulation of water loss via skin [GO:0033561],
response to cytokine [GO:0034097],
megakaryocyte development [GO:0035855],
dorsal aorta morphogenesis [GO:0035912],
mRNA transcription from RNA polymerase II promoter [GO:0042789],
stress fiber assembly [GO:0043149],
skin morphogenesis [GO:0043589],
positive thymic T cell selection [GO:0045059],
sarcomere organization [GO:0045214],
positive regulation of cell differentiation [GO:0045597],
positive regulation of axon extension [GO:0045773],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of smooth muscle contraction [GO:0045987],
positive regulation of transcription by glucose [GO:0046016],
muscle cell cellular homeostasis [GO:0046716],
thymus development [GO:0048538],
developmental growth [GO:0048589],
neuron development [GO:0048666],
erythrocyte development [GO:0048821],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
regulation of smooth muscle cell differentiation [GO:0051150],
positive regulation of filopodium assembly [GO:0051491],
cardiac myofibril assembly [GO:0055003],
angiogenesis involved in wound healing [GO:0060055],
hematopoietic stem cell differentiation [GO:0060218],
positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261],
long term synaptic depression [GO:0060292],
face development [GO:0060324],
heart trabecula formation [GO:0060347],
lung morphogenesis [GO:0060425],
bronchus cartilage development [GO:0060532],
trachea cartilage development [GO:0060534],
cardiac vascular smooth muscle cell differentiation [GO:0060947],
eyelid development in camera-type eye [GO:0061029],
lung smooth muscle development [GO:0061145],
bicellular tight junction assembly [GO:0070830],
cellular response to glucose stimulus [GO:0071333],
primitive streak formation [GO:0090009],
epithelial cell-cell adhesion [GO:0090136],
cellular senescence [GO:0090398],
negative regulation of beta-amyloid clearance [GO:1900222],
negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
in utero embryonic development [GO:0001701],
leukocyte differentiation [GO:0002521],
regulation of transcription, DNA-templated [GO:0006355],
actin filament organization [GO:0007015],
multicellular organism development [GO:0007275],
gastrulation [GO:0007369],
contractile actin filament bundle assembly [GO:0030038],
forebrain development [GO:0030900],
positive regulation of transcription, DNA-templated [GO:0045893],
cell-cell adhesion [GO:0098609],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
serum response element binding [GO:0010736],
chromatin DNA binding [GO:0031490],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
RNA polymerase II sequence-specific DNA binding transcription factor binding [GO:0061629],
primary miRNA binding [GO:0070878],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
sequence-specific DNA binding [GO:0043565],
protein dimerization activity [GO:0046983],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],